2FK8

Crystal structure of Hma (MmaA4) from Mycobacterium tuberculosis complexed with S-adenosylmethionine

Summary for 2FK8

Related2FK7 1KP9 1KPG 1KPH 1KPI 1L1E 1TPY
Descriptormethoxy mycolic acid synthase 4, S-ADENOSYLMETHIONINE (3 entities in total)
Functional Keywordss-adenosylmethionine-dependent methyltransferase fold, transferase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains1
Total molecular weight36919.74
Authors
Boissier, F.,Guillet, V.,Mourey, L. (deposition date: 2006-01-04, release date: 2006-01-17, Last modification date: 2011-07-13)
Primary citation
Boissier, F.,Bardou, F.,Guillet, V.,Uttenweiler-Joseph, S.,Daffe, M.,Quemard, A.,Mourey, L.
Further insight into S-adenosylmethionine-dependent methyltransferases: structural characterization of Hma, an enzyme essential for the biosynthesis of oxygenated mycolic acids in Mycobacterium tuberculosis.
J.Biol.Chem., 281:4434-4445, 2006
PubMed: 16356931 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M510250200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.236200.8%9.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2fk8
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Molmil generated image of 2fk8
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Molmil generated image of 2fk8
rotated about y axis by 90°