5NJI

Structure of the dehydratase domain of PpsC from Mycobacterium tuberculosis in complex with C12:1-CoA

Replaces:  5CF7

Summary for 5NJI

• Entry DOI: 10.2210/pdb5nji/pdb
• Related: 4ooc 5i0k 5l84
• Descriptor: Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC, ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] (~{E})-dodec-2-enethioate (3 entities in total)
• Functional Keywords: dehydratase, polyketide, complex, tuberculosis, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 1
• Total formula weight: 35259.16

Authors

Gavalda, S.,Faille, A.,Mourey, L.,Pedelacq, J.D. (deposition date: 2017-03-28, release date: 2017-05-31, Last modification date: 2024-01-17)

• Primary citation: Faille, A.,Gavalda, S.,Slama, N.,Lherbet, C.,Maveyraud, L.,Guillet, V.,Laval, F.,Quemard, A.,Mourey, L.,Pedelacq, J.D.; Insights into Substrate Modification by Dehydratases from Type I Polyketide Synthases.; J. Mol. Biol., 429:1554-1569, 2017; PubMed: 28377293; DOI: 10.1016/j.jmb.2017.03.026

Experimental method

X-RAY DIFFRACTION (1.6 Å)