2BF8
| Crystal structure of SUMO modified ubiquitin conjugating enzyme E2- 25K | 分子名称: | UBIQUITIN-CONJUGATING ENZYME E2-25 KDA, UBIQUITIN-LIKE PROTEIN SMT3C | 著者 | Pichler, A, Knipscheer, P, Oberhofer, E, Van Dijk, W.J, Korner, R, Velgaard Olsen, J, Jentsch, S, Melchior, F, Sixma, T.K. | 登録日 | 2004-12-06 | 公開日 | 2005-02-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Sumo Imodification of the Ubiquitin Conjugating Enzyme E2-25K Nat.Struct.Mol.Biol., 12, 2005
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2BEP
| Crystal structure of ubiquitin conjugating enzyme E2-25K | 分子名称: | BETA-MERCAPTOETHANOL, UBIQUITIN-CONJUGATING ENZYME E2-25 KDA | 著者 | Pichler, A, Knipscheer, P, Oberhofer, E, Van Dijk, W.J, Korner, R, Velgaard Olsen, J, Jentsch, S, Melchior, F, Sixma, T.K. | 登録日 | 2004-11-29 | 公開日 | 2005-02-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Sumo Imodification of the Ubiquitin Conjugating Enzyme E2-25K Nat.Struct.Mol.Biol., 12, 2005
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3R4S
| Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules | 分子名称: | Botulinum neurotoxin type C1, N-acetyl-alpha-neuraminic acid, N-acetyl-beta-neuraminic acid | 著者 | Strotmeier, J, Gu, S, Jutzi, S, Mahrhold, S, Zhou, J, Pich, A, Bigalke, H, Rummel, A, Jin, R, Binz, T. | 登録日 | 2011-03-17 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol.Microbiol., 81, 2011
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3R4U
| Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules | 分子名称: | Botulinum neurotoxin type C1 | 著者 | Strotmeier, J, Gu, S, Jutzi, S, Mahrhold, S, Zhou, J, Pich, A, Bigalke, H, Rummel, A, Jin, R, Binz, T. | 登録日 | 2011-03-17 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol.Microbiol., 81, 2011
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2QN0
| Structure of Botulinum neurotoxin serotype C1 light chain protease | 分子名称: | Neurotoxin, ZINC ION | 著者 | Jin, R, Sikorra, S, Stegmann, C.M, Pich, A, Binz, T, Brunger, A.T. | 登録日 | 2007-07-17 | 公開日 | 2007-09-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity. Biochemistry, 46, 2007
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4HOR
| Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligocytidine | 分子名称: | Interferon-induced protein with tetratricopeptide repeats 5, MAGNESIUM ION, RNA (5'-R(*(CTP)P*CP*CP*CP*C)-3') | 著者 | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | 登録日 | 2012-10-22 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.861 Å) | 主引用文献 | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOU
| Crystal Structure of N-terminal Human IFIT1 | 分子名称: | Interferon-induced protein with tetratricopeptide repeats 1 | 著者 | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | 登録日 | 2012-10-22 | 公開日 | 2013-01-30 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOT
| Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligoadenine | 分子名称: | Interferon-induced protein with tetratricopeptide repeats 5, MAGNESIUM ION, RNA (5'-R(*(ATP)P*AP*AP*A)-3') | 著者 | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | 登録日 | 2012-10-22 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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2VRR
| Structure of SUMO modified Ubc9 | 分子名称: | FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... | 著者 | Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. | 登録日 | 2008-04-13 | 公開日 | 2008-08-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
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4HOQ
| Crystal Structure of Full-Length Human IFIT5 | 分子名称: | Interferon-induced protein with tetratricopeptide repeats 5 | 著者 | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | 登録日 | 2012-10-22 | 公開日 | 2013-01-23 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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4HOS
| Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine | 分子名称: | Interferon-induced protein with tetratricopeptide repeats 5, RNA (5'-R(*(UTP)P*UP*UP*U)-3'), SODIUM ION | 著者 | Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. | 登録日 | 2012-10-22 | 公開日 | 2013-01-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
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3E3U
| Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor | 分子名称: | N-[(2R)-2-{[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl}hexyl]-N-hydroxyformamide, NICKEL (II) ION, Peptide deformylase | 著者 | Meng, W, Xu, M, Pan, S, Koehn, J. | 登録日 | 2008-08-08 | 公開日 | 2009-01-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results. Bioorg.Med.Chem.Lett., 18, 2008
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3OBR
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3OBT
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8B4A
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7R3H
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7R3E
| Fusion construct of PqsE and RhlR in complex with the synthetic antagonist mBTL | 分子名称: | 2-aminobenzoylacetyl-CoA thioesterase,Regulatory protein RhlR, 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, FE (III) ION | 著者 | Borgert, S.R, Schmelz, S, Blankenfeldt, W. | 登録日 | 2022-02-07 | 公開日 | 2022-12-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.46 Å) | 主引用文献 | Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nat Commun, 13, 2022
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7R3J
| Nativ complex of PqsE and RhlR with the synthetic antagonist mBTL | 分子名称: | 2-aminobenzoylacetyl-CoA thioesterase, 4-(3-bromophenoxy)-N-[(3S)-2-oxothiolan-3-yl]butanamide, FE (III) ION, ... | 著者 | Borgert, S.R, Schmelz, S, Blankenfeldt, W. | 登録日 | 2022-02-07 | 公開日 | 2022-12-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nat Commun, 13, 2022
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7R3G
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7R3F
| Monomeric PqsE mutant E187R | 分子名称: | 2-aminobenzoylacetyl-CoA thioesterase, BENZOIC ACID, CACODYLATE ION, ... | 著者 | Borgert, S.R, Schmelz, S, Blankenfeldt, W. | 登録日 | 2022-02-07 | 公開日 | 2022-12-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nat Commun, 13, 2022
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7R3I
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6IBX
| Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 5 | 分子名称: | 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | 著者 | Banaszak, K, Pawlik, H, Bialas, A, Fabritius, C.H, Nowak, M. | 登録日 | 2018-12-01 | 公開日 | 2019-01-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. Bioorg. Med. Chem. Lett., 29, 2019
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6HVH
| Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 1 | 分子名称: | 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-(oxan-4-yl)pyridine-4-carboxamide, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | 著者 | Banaszak, K, Jakubiec, K, Bialas, A, Fabritius, C.H, Nowak, M. | 登録日 | 2018-10-11 | 公開日 | 2018-11-14 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors. ChemMedChem, 14, 2019
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6HVJ
| Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 3 | 分子名称: | 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 8-(3-methyl-1-benzofuran-5-yl)-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine, ... | 著者 | Banaszak, K, Pawlik, H, Bialas, A, Fabritius, C.H, Nowak, M. | 登録日 | 2018-10-11 | 公開日 | 2018-11-14 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors. ChemMedChem, 14, 2019
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6IBZ
| Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 7 | 分子名称: | 2-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-(pyrimidin-5-ylmethyl)benzenesulfonamide, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | 著者 | Banaszak, K, Tomczyk, M, Guzik, P, Fabritius, C.H, Nowak, M. | 登録日 | 2018-12-01 | 公開日 | 2019-01-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties. Bioorg. Med. Chem. Lett., 29, 2019
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