3E3U

Crystal structure of Mycobacterium tuberculosis peptide deformylase in complex with inhibitor

Summary for 3E3U

Entry DOI	10.2210/pdb3e3u/pdb
Descriptor	Peptide deformylase, NICKEL (II) ION, N-[(2R)-2-{[(2S)-2-(1,3-benzoxazol-2-yl)pyrrolidin-1-yl]carbonyl}hexyl]-N-hydroxyformamide, ... (4 entities in total)
Functional Keywords	metallo-enzyme, hydrolase, iron, metal-binding, protein biosynthesis
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	22096.64
Authors	Meng, W.,Xu, M.,Pan, S.,Koehn, J. (deposition date: 2008-08-08, release date: 2009-01-20, Last modification date: 2024-02-21)
Primary citation	Pichota, A.,Duraiswamy, J.,Yin, Z.,Keller, T.H.,Alam, J.,Liung, S.,Lee, G.,Ding, M.,Wang, G.,Chan, W.L.,Schreiber, M.,Ma, I.,Beer, D.,Ngew, X.,Mukherjee, K.,Nanjundappa, M.,Teo, J.W.,Thayalan, P.,Yap, A.,Dick, T.,Meng, W.,Xu, M.,Koehn, J.,Pan, S.H.,Clark, K.,Xie, X.,Shoen, C.,Cynamon, M. Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results. Bioorg.Med.Chem.Lett., 18:6568-6572, 2008 Cited by PubMed: 19008098 DOI: 10.1016/j.bmcl.2008.10.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation