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6X6C
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BU of 6x6c by Molmil
Cryo-EM structure of NLRP1-DPP9-VbP complex
分子名称: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1, ...
著者Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
登録日2020-05-27
公開日2021-03-10
最終更新日2021-05-12
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6X6A
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BU of 6x6a by Molmil
Cryo-EM structure of NLRP1-DPP9 complex
分子名称: Dipeptidyl peptidase 9, NACHT, LRR and PYD domains-containing protein 1
著者Hollingsworth, L.R, Sharif, H, Griswold, A.R, Fontana, P, Mintseris, J, Dagbay, K.B, Paulo, J.A, Gygi, S.P, Bachovchin, D.A, Wu, H.
登録日2020-05-27
公開日2021-03-10
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Nature, 592, 2021
6ZVH
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BU of 6zvh by Molmil
EDF1-ribosome complex
分子名称: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
著者Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R.
登録日2020-07-24
公開日2020-08-19
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
6ZVI
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BU of 6zvi by Molmil
Mbf1-ribosome complex
分子名称: 18S rRNA, 40S ribosomal protein S0-A, 40S ribosomal protein S10-A, ...
著者Best, K.M, Denk, T, Cheng, J, Thoms, M, Berninghausen, O, Beckmann, R.
登録日2020-07-24
公開日2020-09-09
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献EDF1 coordinates cellular responses to ribosome collisions.
Elife, 9, 2020
8OJ5
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BU of 8oj5 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution)
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Penchev, I, DaRosa, P.A, Peter, J.J, Kulathu, Y, Becker, T, Beckmann, R, Kopito, R.
登録日2023-03-23
公開日2024-02-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OJ0
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BU of 8oj0 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native)
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
登録日2023-03-23
公開日2024-02-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OHD
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BU of 8ohd by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native)
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
登録日2023-03-21
公開日2024-02-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
8OJ8
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BU of 8oj8 by Molmil
60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native)
分子名称: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
著者Penchev, I, DaRosa, P.A, Becker, T, Beckmann, R, Kopito, R.
登録日2023-03-24
公開日2024-02-21
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
Nature, 627, 2024
7TMW
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BU of 7tmw by Molmil
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
分子名称: Camelid antibody VHH fragment Nb35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Erlandson, S.C, Rawson, S, Kruse, A.C.
登録日2022-01-20
公開日2023-02-15
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The relaxin receptor RXFP1 signals through a mechanism of autoinhibition.
Nat.Chem.Biol., 19, 2023
7T9X
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BU of 7t9x by Molmil
Saccharomyces cerevisiae Pex12 RING domain
分子名称: Peroxisome assembly protein 12, ZINC ION
著者Feng, P, Rapoport, T.
登録日2021-12-20
公開日2022-06-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Nature, 607, 2022
7T92
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BU of 7t92 by Molmil
Structure of the peroxisomal retro-translocon formed by a heterotrimeric ubiquitin ligase complex
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, CHOLESTEROL, Fab heavy chain, ...
著者Peiqiang, F, Tom, R.
登録日2021-12-17
公開日2022-07-06
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献A peroxisomal ubiquitin ligase complex forms a retrotranslocation channel.
Nature, 607, 2022
6BOF
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BU of 6bof by Molmil
Crystal structure of KRAS A146T-GDP demonstrating open switch 1 conformation
分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
著者Bera, A.K, Yan, W, Westover, K.D.
登録日2017-11-20
公開日2019-05-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov, 9, 2019
6MA2
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BU of 6ma2 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor ent-1a
分子名称: Host Cell Factor 1 peptide, N-[(2S)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}acetyl]-N-[(thiophen-2-yl)methyl]glycine, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
著者Martin, S.E.S, Lazarus, M.B, Walker, S.
登録日2018-08-25
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA3
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BU of 6ma3 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 2a
分子名称: 4-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl)methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}butanoic acid, Host Cell Factor 1 peptide, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
著者Martin, S.E.S, Lazarus, M.B, Walker, S.
登録日2018-08-25
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA5
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BU of 6ma5 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 1a
分子名称: Host Cell Factor 1 peptide, N-[(2R)-2-(2-methoxyphenyl)-2-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}acetyl]-N-[(thiophen-2-yl)methyl]glycine, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
著者Martin, S.E.S, Lazarus, M.B, Walker, S.
登録日2018-08-25
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA1
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BU of 6ma1 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 4a
分子名称: Host Cell Factor 1 peptide, N-[(2R)-2-{[(7-chloro-2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}-2-(2-methoxyphenyl)acetyl]-N-[(thiophen-2-yl)methyl]glycine, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
著者Martin, S.E.S, Lazarus, M.B, Walker, S.
登録日2018-08-25
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
6MA4
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BU of 6ma4 by Molmil
Crystal structure of human O-GlcNAc transferase bound to a peptide from HCF-1 pro-repeat 2 (11-26) and inhibitor 3a
分子名称: 5-{2-[(1R)-2-{(carboxymethyl)[(thiophen-2-yl)methyl]amino}-2-oxo-1-{[(2-oxo-1,2-dihydroquinolin-6-yl)sulfonyl]amino}ethyl]phenoxy}pentanoic acid, Host Cell Factor 1 peptide, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
著者Martin, S.E.S, Lazarus, M.B, Walker, S.
登録日2018-08-25
公開日2018-10-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
J. Am. Chem. Soc., 140, 2018
7LS5
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BU of 7ls5 by Molmil
Cryo-EM structure of the Pre3-1 20S proteasome core particle
分子名称: Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, ...
著者Schnell, H.M, Walsh Jr, R.M, Rawson, S, Hanna, J.W.
登録日2021-02-17
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis.
Nat.Struct.Mol.Biol., 28, 2021
7LS6
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BU of 7ls6 by Molmil
Cryo-EM structure of Pre-15S proteasome core particle assembly intermediate purified from Pre3-1 proteasome mutant (G34D)
分子名称: Proteasome assembly chaperone 2, Proteasome chaperone 1, Proteasome maturation factor UMP1, ...
著者Schnell, H.M, Walsh Jr, R.M, Rawson, S, Hanna, J.W.
登録日2021-02-17
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis.
Nat.Struct.Mol.Biol., 28, 2021
7LSX
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BU of 7lsx by Molmil
Cryo-EM structure of 13S proteasome core particle assembly intermediate purified from Pre3-1 proteasome mutant (G34D)
分子名称: Proteasome assembly chaperone 2, Proteasome chaperone 1, Proteasome maturation factor UMP1, ...
著者Schnell, H.M, Walsh Jr, R.M, Rawson, S, Hanna, J.W.
登録日2021-02-18
公開日2021-04-14
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis.
Nat.Struct.Mol.Biol., 28, 2021
6BOX
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BU of 6box by Molmil
Structure of the S. pombe Clr4 catalytic domain bound to SAH
分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Currie, M.A, Moazed, D.
登録日2017-11-21
公開日2018-07-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.412 Å)
主引用文献Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Nature, 560, 2018
6BP4
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BU of 6bp4 by Molmil
Structure of the S. pombe Clr4 catalytic domain bound to SAM
分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific, S-ADENOSYLMETHIONINE, ...
著者Currie, M.A, Moazed, D.
登録日2017-11-21
公開日2018-07-25
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7701 Å)
主引用文献Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
Nature, 560, 2018
7JIF
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BU of 7jif by Molmil
HRAS A59T GppNHp
分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
著者Johnson, C.W, Haigis, K.M.
登録日2020-07-23
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.757 Å)
主引用文献Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
7JII
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HRAS A59E GDP
分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ...
著者Johnson, C.W, Haigis, K.M.
登録日2020-07-23
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.532 Å)
主引用文献Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
7JIH
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HRAS A59E GppNHp
分子名称: GLYCEROL, GTPase HRas, MAGNESIUM ION, ...
著者Johnson, C.W, Haigis, K.M.
登録日2020-07-23
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.989 Å)
主引用文献Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022

 

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