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9B1R
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Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 from Arabidopsis thaliana
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Vacuolar-sorting receptor 1
著者Park, H, Youn, B, Park, D.J, Puthanveettil, S.V, Kang, C.
登録日2024-03-13
公開日2024-05-15
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Functional implication of the homotrimeric multidomain vacuolar sorting receptor 1 (VSR1) from Arabidopsis thaliana.
Sci Rep, 14, 2024
4W4X
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JNK2/3 in complex with 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
分子名称: 3-(4-{[(4-fluorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
8EFJ
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A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds
分子名称: (4P)-4-[5-(2-chloro-6-fluoroanilino)-6-(methoxymethyl)-1H-indazol-1-yl]-N-methylthiophene-2-carboxamide, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
著者Park, H, Feng, Y.
登録日2022-09-08
公開日2023-09-20
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds
To Be Published
4W4V
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JNK2/3 in complex with 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
分子名称: 3-(4-{[(2-chlorophenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-Jun N-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4Y
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JNK2/3 in complex with 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide
分子名称: 3-(4-{[(4-methylphenyl)carbamoyl]amino}-1H-pyrazol-1-yl)-N-(2-methylpyridin-4-yl)benzamide, c-jun NH2-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
4W4W
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JNK2/3 in complex with N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide
分子名称: N-(2-methylpyridin-4-yl)-3-{4-[(phenylcarbamoyl)amino]-1H-pyrazol-1-yl}benzamide, c-Jun N-terminal kinase 3
著者Park, H, Iqbal, S, Hernandez, P, Mora, R, Zheng, K, Feng, Y, LoGrasso, P.
登録日2014-08-15
公開日2015-02-11
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles.
Sci Rep, 5, 2015
6N2U
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BU of 6n2u by Molmil
IL-8 Structure from Bacterial Expression Source
分子名称: Interleukin-8
著者Park, H, Jung, J.H, Luo, J.L.
登録日2018-11-14
公開日2019-11-20
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.254 Å)
主引用文献IL-8 Structure from Bacterial Expression Source
To Be Published
3O3U
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Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)
分子名称: Maltose-binding periplasmic protein, Advanced glycosylation end product-specific receptor, SULFATE ION, ...
著者Park, H, Boyington, J.C.
登録日2010-07-26
公開日2010-10-13
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.497 Å)
主引用文献The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding.
J.Biol.Chem., 285, 2010
5BTM
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Crystal structure of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10)
分子名称: MAGNESIUM ION, RNA (55-mer), SODIUM ION
著者Park, H.
登録日2015-06-03
公開日2015-07-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.778 Å)
主引用文献Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).
Biochemistry, 54, 2015
1RF4
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Structural Studies of Streptococcus pneumoniae EPSP Synthase, Tetrahedral intermediate Bound State
分子名称: (3R,4S,5R)-5-{[(1R)-1-CARBOXY-2-FLUORO-1-(PHOSPHONOOXY)ETHYL]OXY}-4-HYDROXY-3-(PHOSPHONOOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 5-enolpyruvylshikimate-3-phosphate synthase
著者Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
登録日2003-11-07
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF5
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Structural Studies of Streptococcus pneumoniae EPSP Synthase in Unliganded State
分子名称: 5-enolpyruvylshikimate-3-phosphate synthase
著者Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
登録日2003-11-07
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1RF6
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BU of 1rf6 by Molmil
Structural Studies of Streptococcus pneumoniae EPSP Synthase in S3P-GLP Bound State
分子名称: 5-enolpyruvylshikimate-3-phosphate synthase, GLYPHOSATE, SHIKIMATE-3-PHOSPHATE
著者Park, H, Hilsenbeck, J.L, Kim, H.J, Shuttleworth, W.A, Park, Y.H, Evans, J.N, Kang, C.
登録日2003-11-07
公開日2004-02-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural studies of Streptococcus pneumoniae EPSP synthase in unliganded state, tetrahedral intermediate-bound state and S3P-GLP-bound state.
Mol.Microbiol., 51, 2004
1N4E
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Crystal Structure of a DNA Decamer Containing a Thymine-dimer
分子名称: 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*AP*TP*TP*CP*G)-3'
著者Park, H, Zhang, K, Ren, Y, Nadji, S, Sinha, N, Taylor, J.-S, Kang, C.
登録日2002-10-30
公開日2003-02-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of a DNA decamer containing a cis-syn thymine dimer.
Proc.Natl.Acad.Sci.USA, 99, 2002
3RF3
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BU of 3rf3 by Molmil
Shigella IpaA-VBS3 in complex with human vinculin
分子名称: CACODYLATE ION, Invasin ipaA, Vinculin
著者Park, H, Sharff, A, Izard, T.
登録日2011-04-05
公開日2011-04-27
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Novel vinculin binding site of the IpaA invasin of Shigella.
J.Biol.Chem., 286, 2011
1YPU
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Human Oxidized Low Density Lipoprotein Receptor LOX-1 C2 Space Group
分子名称: oxidised low density lipoprotein (lectin-like) receptor 1
著者Park, H, Adsit, F.G, Boyington, J.C.
登録日2005-01-31
公開日2005-02-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1YPQ
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Human Oxidized Low Density Lipoprotein Receptor LOX-1 Dioxane Complex
分子名称: 1,4-DIETHYLENE DIOXIDE, oxidised low density lipoprotein (lectin-like) receptor 1
著者Park, H, Adsit, F.G, Boyington, J.C.
登録日2005-01-31
公開日2005-02-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1YPO
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Human Oxidized Low Density Lipoprotein Receptor LOX-1 P3 1 21 Space Group
分子名称: oxidised low density lipoprotein (lectin-like) receptor 1
著者Park, H, Adsit, F.G, Boyington, J.C.
登録日2005-01-31
公開日2005-02-08
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The 1.4 angstrom crystal structure of the human oxidized low density lipoprotein receptor lox-1.
J.Biol.Chem., 280, 2005
1SM5
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Crystal Structure of a DNA Decamer Containing a Thymine-dimer
分子名称: 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*(BRU)P*TP*AP*AP*TP*(BRU)P*CP*G)-3'
著者Park, H, Zhang, K, Ren, Y, Nadji, S, Sinha, N, Taylor, J.-S, Kang, C.
登録日2004-03-08
公開日2004-05-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of a DNA Decamer Containing a Thymine-dimer
Proc.Natl.Acad.Sci.USA, 99, 2002
1T4I
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Crystal Structure of a DNA Decamer Containing a Thymine-dimer
分子名称: 5'-D(*CP*GP*AP*AP*TP*TP*AP*AP*GP*C)-3', 5'-D(*GP*CP*TP*TP*AP*AP*TP*TP*CP*G)-3'
著者Park, H, Zhang, K, Ren, Y, Nadji, S, Sinha, N, Taylor, J.S, Kang, C.
登録日2004-04-29
公開日2004-05-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of a DNA Decamer Containing a cis-syn Thymine-dimer
Proc.Natl.Acad.Sci.USA, 99, 2002
3TJ6
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human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii
分子名称: Antigenic heat-stable 120 kDa protein, Vinculin
著者Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T.
登録日2011-08-23
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
3TJ5
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human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-N; residues 412-434) from Rickettsia rickettsii
分子名称: Antigenic heat-stable 120 kDa protein, GLYCEROL, Vinculin
著者Park, H, Lee, J.H, Gouin, E, Cossart, P, Izard, T.
登録日2011-08-23
公開日2011-09-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286, 2011
6BA5
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Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
分子名称: Inactive tyrosine-protein kinase transmembrane receptor ROR1, Variable domain Heavy chain, antibody R11, ...
著者Park, H, Rader, C.
登録日2017-10-12
公開日2018-06-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
8ENJ
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Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)
分子名称: Mitogen-activated protein kinase 10, N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide
著者Park, H, Mersal, K.I.
登録日2022-09-30
公開日2023-10-18
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.
Eur.J.Med.Chem., 261, 2023
4Y46
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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
分子名称: 1-{trans-4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]cyclohexyl}-3-propan-2-ylurea, Mitogen-activated protein kinase 10
著者Park, H.
登録日2015-02-10
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015
4Y5H
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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
分子名称: 1-(trans-4-{[7-oxo-8-(propan-2-yl)-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}cyclohexyl)-3-propan-2-ylurea, Mitogen-activated protein kinase 10
著者Park, H.
登録日2015-02-11
公開日2015-05-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.055 Å)
主引用文献Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Acs Med.Chem.Lett., 6, 2015

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