8VM2
 
 | | Crystal Structure of NRAS Q61K bound to GTP | | 分子名称: | GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M. | | 登録日 | 2024-01-12 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.
Eur J Cell Biol, 103, 2024
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7RSC
 | | NMR-driven structure of the KRAS4B-G12D "alpha-alpha" dimer on a lipid bilayer nanodisc | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | | 登録日 | 2021-08-11 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
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7RSE
 | | NMR-driven structure of the KRAS4B-G12D "alpha-beta" dimer on a lipid bilayer nanodisc | | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Apolipoprotein A-I, GTPase KRas, ... | | 著者 | Lee, K, Enomoto, M, Gebregiworgis, T, Gasmi-Seabrook, G.M, Ikura, M, Marshall, C.B. | | 登録日 | 2021-08-11 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.
Chem Sci, 12, 2021
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2ERB
 | | AgamOBP1, and odorant binding protein from Anopheles gambiae complexed with PEG | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, MAGNESIUM ION, odorant binding protein | | 著者 | Wogulis, M, Morgan, T, Ishida, Y, Leal, W.S, Wilson, D.K. | | 登録日 | 2005-10-24 | | 公開日 | 2005-12-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The crystal structure of an odorant binding protein from Anopheles gambiae: Evidence for a common ligand release mechanism.
Biochem.Biophys.Res.Commun., 339, 2006
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6OS4
 | | Calmodulin in complex with farnesyl cysteine methyl ester | | 分子名称: | CALCIUM ION, Calmodulin-1, s-farnesyl-l-cysteine methyl ester | | 著者 | Grant, B.M.M, Enomoto, M, Lee, K.Y, Back, S.I, Gebregiworgis, T, Ishiyama, N, Ikura, M, Marshall, C. | | 登録日 | 2019-05-01 | | 公開日 | 2020-04-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety.
Sci.Signal., 13, 2020
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2KE1
 | | Molecular Basis of non-modified histone H3 tail Recognition by the First PHD Finger of Autoimmune Regulator | | 分子名称: | Autoimmune regulator, H3K4me0, ZINC ION | | 著者 | Chignola, F, Gaetani, M, Rebane, A, Org, T, Mollica, L, Zucchelli, C, Spitaleri, A, Mannella, V, Peterson, P, Musco, G. | | 登録日 | 2009-01-22 | | 公開日 | 2009-05-26 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation
Nucleic Acids Res., 37, 2009
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1Q5K
 | | crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor | | 分子名称: | Glycogen synthase kinase-3 beta, N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA | | 著者 | Bhat, R, Xue, Y, Berg, S, Hellberg, S, Ormo, M, Nilsson, Y, Radesater, A.C, Jerning, E, Markgren, P.O, Borgegard, T, Nylof, M, Gimenez-Cassina, A, Hernandez, F, Lucas, J.J, Diaz-Mido, J, Avila, J. | | 登録日 | 2003-08-08 | | 公開日 | 2004-08-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
J.Biol.Chem., 278, 2003
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1T3O
 | | Solution structure of CsrA, a bacterial carbon storage regulatory protein | | 分子名称: | Carbon storage regulator | | 著者 | Koharudin, L.M.I, Georgiou, T, Kleanthous, C, Geoffrey, R, Kaptein, R, Boelens, R. | | 登録日 | 2004-04-27 | | 公開日 | 2005-10-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A model for RNA binding by the bacterial carbon storage regulatory protein, CsrA
To be Published
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2JZC
 | | NMR solution structure of ALG13: The sugar donor subunit of a yeast N-acetylglucosamine transferase. Northeast Structural Genomics Consortium target YG1 | | 分子名称: | UDP-N-acetylglucosamine transferase subunit ALG13 | | 著者 | Wang, X, Weldeghorghis, T, Zhang, G, Imepriali, B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2008-01-04 | | 公開日 | 2008-02-19 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of Alg13: the sugar donor subunit of a yeast N-acetylglucosamine transferase.
Structure, 16, 2008
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2W9D
 | | Structure of Fab fragment of the ICSM 18 - anti-Prp therapeutic antibody at 1.57 A resolution. | | 分子名称: | CALCIUM ION, ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN | | 著者 | Antonyuk, S.V, Trevitt, C.R, Strange, R.W, Jackson, G.S, Sangar, D, Batchelor, M, Jones, S, Georgiou, T, Cooper, S, Fraser, C, Khalili-Shirazi, A, Clarke, A.R, Hasnain, S.S, Collinge, J. | | 登録日 | 2009-01-23 | | 公開日 | 2009-02-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Crystal Structure of Human Prion Protein Bound to a Therapeutic Antibody.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2W9E
 | | Structure of ICSM 18 (anti-Prp therapeutic antibody) Fab fragment complexed with human Prp fragment 119-231 | | 分子名称: | ICSM 18-ANTI-PRP THERAPEUTIC FAB HEAVY CHAIN, ICSM 18-ANTI-PRP THERAPEUTIC FAB LIGHT CHAIN, MAJOR PRION PROTEIN, ... | | 著者 | Antonyuk, S.V, Trevitt, C.R, Strange, R.W, Jackson, G.S, Sangar, D, Batchelor, M, Jones, S, Georgiou, T, Cooper, S, Fraser, C, Khalili-Shirazi, A, Clarke, A.R, Hasnain, S.S, Collinge, J. | | 登録日 | 2009-01-23 | | 公開日 | 2009-02-03 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure of Human Prion Protein Bound to a Therapeutic Antibody.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2JS1
 | | Solution NMR structure of the homodimer protein YVFG from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR478 | | 分子名称: | Uncharacterized protein yvfG | | 著者 | Macnaughtan, M.A, Weldeghiorghis, T, Wang, X, Bansal, S, Tian, F, Wang, D, Janjua, H, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M.C, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2007-06-29 | | 公開日 | 2007-07-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Structure of the Bacillus subtilis Protein YvfG.
To be Published
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3MNF
 | | Crystal structure of PAC2 family protein from Streptomyces avermitilis MA | | 分子名称: | CHLORIDE ION, PAC2 family protein | | 著者 | Chang, C, Hatzos, C, Morgan, T, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2010-04-21 | | 公開日 | 2010-05-05 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | | 主引用文献 | Crystal structure of PAC2 family protein from Streptomyces avermitilis MA
To be Published
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3KKC
 | | The crystal structure OF TetR transcriptional regulator from Streptococcus agalactiae 2603V | | 分子名称: | IMIDAZOLE, NICKEL (II) ION, TetR family Transcriptional regulator | | 著者 | Tan, K, Hatzos, C, Morgan, T, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2009-11-05 | | 公開日 | 2009-11-17 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The crystal structure OF TetR transcriptional regulator from Streptococcus agalactiae 2603V
To be Published
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6H1F
 | | Structure of the nanobody-stabilized gelsolin D187N variant (second domain) | | 分子名称: | Gelsolin, THIOCYANATE ION, gelsolin nanobody, ... | | 著者 | Hassan, A, Milani, M, Mastrangelo, E, de Rosa, M. | | 登録日 | 2018-07-11 | | 公開日 | 2019-01-23 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant.
Biochim Biophys Acta Mol Basis Dis, 1865, 2019
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1TYC
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1TYD
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1TYB
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1TYA
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6DKS
 | | Structure of the Rbpj-SHARP-DNA Repressor Complex | | 分子名称: | DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Maltose/maltodextrin-binding periplasmic protein, ... | | 著者 | Kovall, R.A, VanderWielen, B.D, Yuan, Z. | | 登録日 | 2018-05-30 | | 公開日 | 2019-01-02 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site.
Cell Rep, 26, 2019
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6OCW
 | | Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A85 | | 分子名称: | CITRIC ACID, DIMETHYLFORMAMIDE, N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-4-[(2S)-2-methylpiperidin-1-yl]-1,4-dioxobutan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name), ... | | 著者 | Hsu, H.C, Li, H. | | 登録日 | 2019-03-25 | | 公開日 | 2019-10-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome.
J.Med.Chem., 62, 2019
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6ODE
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1BEG
 | | STRUCTURE OF FUNGAL ELICITOR, NMR, 18 STRUCTURES | | 分子名称: | BETA-ELICITIN CRYPTOGEIN | | 著者 | Fefeu, S, Bouaziz, S, Huet, J.-C, Pernollet, J.-C, Guittet, E. | | 登録日 | 1996-11-26 | | 公開日 | 1997-12-03 | | 最終更新日 | 2022-02-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional solution structure of beta cryptogein, a beta elicitin secreted by a phytopathogenic fungus Phytophthora cryptogea.
Protein Sci., 6, 1997
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6OCZ
 | | Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A86 | | 分子名称: | CITRIC ACID, DIMETHYLFORMAMIDE, N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name), ... | | 著者 | Hsu, H.C, Li, H. | | 登録日 | 2019-03-25 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome.
J.Med.Chem., 62, 2019
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6Q9Z
 | | Crystal structure of the pathological G167R variant of calcium-free human gelsolin, | | 分子名称: | GLYCEROL, Gelsolin, SULFATE ION | | 著者 | Boni, F, Scalone, E, Milani, M, Eloise, M, de Rosa, M. | | 登録日 | 2018-12-18 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | The structure of N184K amyloidogenic variant of gelsolin highlights the role of the H-bond network for protein stability and aggregation properties.
Eur.Biophys.J., 49, 2020
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