2E56
 
 | | Crystal structure of human MD-2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte antigen 96, MYRISTIC ACID | | 著者 | Ohto, U, Satow, Y. | | 登録日 | 2006-12-19 | | 公開日 | 2007-06-26 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa.
Science, 316, 2007
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1UJ3
 | | Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor | | 分子名称: | IgG Fab heavy chain, IgG Fab light chain, tissue factor | | 著者 | Ohto, U, Mizutani, R, Nakamura, M, Adachi, H, Satow, Y. | | 登録日 | 2003-07-25 | | 公開日 | 2004-07-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of a humanized Fab fragment of anti-tissue-factor antibody in complex with tissue factor.
J.Synchrotron Radiat., 11, 2004
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5JK9
 | | Crystal structure of human IZUMO1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Izumo sperm-egg fusion protein 1 | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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5JKC
 | | Crystal structure of human IZUMO1-JUNO complex (crystal form 1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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5JKD
 | | Crystal structure of human IZUMO1-JUNO complex (crystal form 2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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3T6Q
 | | Crystal structure of mouse RP105/MD-1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD180 antigen, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2011-07-28 | | 公開日 | 2011-11-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
J.Mol.Biol., 413, 2011
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3THC
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3THD
 | | Crystal structure of human beta-galactosidase in complex with 1-deoxygalactonojirimycin | | 分子名称: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2011-08-18 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Crystal structure of human beta-galactosidase: structural basis of Gm1 gangliosidosis and morquio B diseases
J.Biol.Chem., 287, 2012
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4G8A
 | | Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS | | 分子名称: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2012-07-23 | | 公開日 | 2012-10-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I
J.Biol.Chem., 287, 2012
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2E59
 | | Crystal structure of human MD-2 in complex with lipid IVa | | 分子名称: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-4-O-phosphono-beta-D-glucopyranose, ... | | 著者 | Ohto, U, Satow, Y. | | 登録日 | 2006-12-19 | | 公開日 | 2007-06-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
Science, 316, 2007
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7VTQ
 | | Cryo-EM structure of mouse NLRP3 (full-length) dodecamer | | 分子名称: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2021-10-30 | | 公開日 | 2022-03-09 | | 最終更新日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VTP
 | | Cryo-EM structure of PYD-deleted human NLRP3 hexamer | | 分子名称: | 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2021-10-30 | | 公開日 | 2022-03-09 | | 最終更新日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | | 主引用文献 | Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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5JKA
 | | Crystal structure of human JUNO (crystal form 1) | | 分子名称: | CHLORIDE ION, Sperm-egg fusion protein Juno, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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5JKB
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5JKE
 | | Crystal structure of human IZUMO1-JUNO complex (crystal form 3) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2016-04-26 | | 公開日 | 2016-06-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization
Nature, 534, 2016
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3B2D
 | | Crystal structure of human RP105/MD-1 complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD180 antigen, ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2011-07-29 | | 公開日 | 2011-11-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
J.Mol.Biol., 413, 2011
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5Y3L
 | | Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and CCGCAC DNA) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2017-07-29 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
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5Y3J
 | | Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and TCGCAC DNA) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ... | | 著者 | Ohto, U, Ishida, H, Shimizu, T. | | 登録日 | 2017-07-29 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
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5Y3K
 | | Crystal structure of horse TLR9 in complex with two DNAs (CpG DNA and GCGCAC DNA) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ... | | 著者 | Ohto, U, Shimizu, T. | | 登録日 | 2017-07-29 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation
Immunity, 48, 2018
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5Y3M
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3WPF
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3WPD
 | | Crystal structure of horse TLR9 in complex with inhibitory DNA4084 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*G)-3'), ... | | 著者 | Ohto, U, Tanji, H, Shimizu, T. | | 登録日 | 2014-01-11 | | 公開日 | 2015-02-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
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3WPI
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3WPE
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3WPC
 | | Crystal structure of horse TLR9 in complex with agonistic DNA1668_12mer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*AP*TP*GP*AP*CP*GP*TP*TP*CP*CP*T)-3'), ... | | 著者 | Ohto, U, Tanji, H, Shimizu, T. | | 登録日 | 2014-01-11 | | 公開日 | 2015-02-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
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