6Z2B
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5NFJ
| Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM) | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Mitochondrial ribonuclease P protein 1, ... | 著者 | Oerum, S, Kopec, J, Fitzpatrick, F, Newman, J.A, Chalk, R, Shrestha, L, Fairhead, M, Talon, R, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, C, Bountra, C, Oppermann, U, Yue, W.W, Structural Genomics Consortium (SGC) | 登録日 | 2017-03-14 | 公開日 | 2018-05-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM) To Be Published
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6TGJ
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6TNN
| Mini-RNase III (Mini-III) bound to 50S ribosome with precursor 23S rRNA | 分子名称: | 50S ribosomal protein L10, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Oerum, S, Dendooven, T, Gilet, L, Catala, M, Degut, C, Trinquier, A, Barraud, P, Luisi, B, Condon, C, Tisne, C. | 登録日 | 2019-12-09 | 公開日 | 2020-09-30 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Mol.Cell, 80, 2020
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6TG6
| Toprim domain of RNase M5 | 分子名称: | Ribonuclease M5 | 著者 | Oerum, S, Catala, M, Tisne, C. | 登録日 | 2019-11-15 | 公開日 | 2020-09-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Mol.Cell, 80, 2020
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6TPQ
| RNase M5 bound to 50S ribosome with precursor 5S rRNA | 分子名称: | 50S ribosomal protein L10, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Oerum, S, Dendooven, T, Gilet, L, Catala, M, Degut, C, Trinquier, A, Barraud, P, Luisi, B, Condon, C, Tisne, C. | 登録日 | 2019-12-13 | 公開日 | 2020-09-30 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs. Mol.Cell, 80, 2020
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6QE6
| Structure of M. capricolum TrmK in complex with the natural cofactor product S-adenosyl-homocysteine (SAH) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, tRNA (Adenine(22)-N(1))-methyltransferase | 著者 | Oerum, S, Catala, M, Atdjian, C, Brachet, F, Ponchon, L, Barraud, P, Iannazzo, L, Droogmans, L, Braud, E, Etheve-Quelquejeu, M, Tisne, C. | 登録日 | 2019-01-04 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites. Rna Biol., 16, 2019
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6QE5
| Structure of E.coli RlmJ in complex with the natural cofactor product S-adenosyl-homocysteine (SAH) | 分子名称: | Ribosomal RNA large subunit methyltransferase J, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Oerum, S, Catala, M, Atdjian, C, Brachet, F, Ponchon, L, Barraud, P, Iannazzo, L, Droogmans, L, Braud, E, Etheve-Quelquejeu, M, Tisne, C. | 登録日 | 2019-01-04 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites. Rna Biol., 16, 2019
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6QDX
| Structure of E.coli RlmJ in complex with a bisubstrate analogue (BA4) | 分子名称: | (2~{S})-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{S},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid, Ribosomal RNA large subunit methyltransferase J | 著者 | Oerum, S, Catala, M, Atdjian, C, Brachet, F, Ponchon, L, Barraud, P, Iannazzo, L, Droogmans, L, Braud, E, Etheve-Quelquejeu, M, Tisne, C. | 登録日 | 2019-01-03 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites. Rna Biol., 16, 2019
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6QE0
| Structure of E.coli RlmJ in complex with a bisubstrate analogue (BA2) | 分子名称: | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid, Ribosomal RNA large subunit methyltransferase J | 著者 | Oerum, S, Catala, M, Atdjian, C, Brachet, F, Ponchon, L, Barraud, P, Iannazzo, L, Droogmans, L, Braud, E, Etheve-Quelquejeu, M, Tisne, C. | 登録日 | 2019-01-03 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.394 Å) | 主引用文献 | Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites. Rna Biol., 16, 2019
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5NXD
| LIM Domain Kinase 2 (LIMK2) In Complex With TH-300 | 分子名称: | 1,2-ETHANEDIOL, 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide, LIM domain kinase 2 | 著者 | Mathea, S, Salah, E, Hanke, T, Newman, J.A, Oerum, S, Wang, D, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N, Knapp, S. | 登録日 | 2017-05-10 | 公開日 | 2017-05-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | LIM Domain Kinase 2 (LIMK2)In Complex With TH-300 To Be Published
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5FXV
| Crystal structure of JmjC domain of human histone demethylase UTY in complex with N05859b | 分子名称: | 1,2-ETHANEDIOL, 4-CARBOXYPIPERIDINE, HISTONE DEMETHYLASE UTY, ... | 著者 | Nowak, R, Krojer, T, Johansson, C, Gileadi, C, Kupinska, K, Srikannathasan, V, Oerum, S, Pearce, N.M, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. | 登録日 | 2016-03-03 | 公開日 | 2016-03-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with N05859B To be Published
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7P9O
| Structure of E.coli RlmJ in complex with a SAM analogue (CA) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl]amino}-5'-deoxyadenosine, Ribosomal RNA large subunit methyltransferase J | 著者 | Meynier, V, Catala, M, Oerum, S, Barraud, P, Tisne, C. | 登録日 | 2021-07-27 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.095 Å) | 主引用文献 | Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase. Nucleic Acids Res., 50, 2022
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7P8Q
| Structure of E.coli RlmJ in complex with an RNA conjugate (GA-SAM) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine, RNA conjugate (GA-SAM), Ribosomal RNA large subunit methyltransferase J | 著者 | Meynier, V, Catala, M, Oerum, S, Barraud, P, Tisne, C. | 登録日 | 2021-07-23 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | 主引用文献 | Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase. Nucleic Acids Res., 50, 2022
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7P9I
| Structure of E.coli RlmJ in complex with an RNA conjugate (GAA-SAM) | 分子名称: | 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine, RNA conjugate (GAA-SAM), Ribosomal RNA large subunit methyltransferase J | 著者 | Meynier, V, Catala, M, Oerum, S, Barraud, P, Tisne, C. | 登録日 | 2021-07-27 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.594 Å) | 主引用文献 | Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase. Nucleic Acids Res., 50, 2022
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8CBO
| Structure of human mitochondrial MRPP1-MRPP2 in complex with mitochondrial pre-tRNA-Ile | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, Mitochondrial Precursor tRNA-Ile(5,4), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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8CBK
| Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-His(5,Ser) | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, MAGNESIUM ION, Mitochondrial Precursor tRNA-His(5,Ser), ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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8CBL
| Structure of human mitochondrial RNase Z in complex with mitochondrial pre-tRNA-His(0,Ser) | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, Mitochondrial Precursor tRNA-His(0,Ser), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, YU, W, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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8CBM
| Structure of human mitochondrial CCA-adding enzyme in complex with mitochondrial pre-tRNA-Ile | 分子名称: | 3-hydroxyacyl-CoA dehydrogenase type-2, CCA tRNA nucleotidyltransferase 1, mitochondrial, ... | 著者 | MEYNIER, V, HARDWICK, S, CATALA, M, ROSKE, J, OERUM, S, CHIRGADZE, D, BARRAUD, P, LUISI, B, TISNE, C. | 登録日 | 2023-01-25 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural basis for human mitochondrial tRNA maturation. Nat Commun, 15, 2024
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5LF8
| Human Nucleoside diphosphate-linked moiety X motif 17 (NUDT17) | 分子名称: | ETHYL MERCURY ION, Nucleoside diphosphate-linked moiety X motif 17, PHOSPHATE ION | 著者 | Mathea, S, Tallant, C, Salah, E, Wang, D, Velupillai, S, Nowak, R, Oerum, S, Krojer, T, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Huber, K, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-30 | 公開日 | 2017-08-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Human Nucleoside diphosphate-linked moiety X motif 17 (NUDT17) To Be Published
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5L6W
| Structure Of the LIMK1-ATPgammaS-CFL1 Complex | 分子名称: | Cofilin-1, LIM domain kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Salah, E, Mathea, S, Oerum, S, Newman, J.A, Tallant, C, Adamson, R, Canning, P, Beltrami, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Bullock, A.N. | 登録日 | 2016-05-31 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structure Of the LIMK1-ATPgammaS-CFL1 Complex To Be Published
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6I2Y
| Human STK10 bound to Foretinib | 分子名称: | N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, Serine/threonine-protein kinase 10 | 著者 | Sorrell, F.J, Berger, B.-T, Oerum, S, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Elkins, J.M. | 登録日 | 2018-11-02 | 公開日 | 2018-12-12 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Human STK10 bound to GW683134 To Be Published
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