6QDX

Structure of E.coli RlmJ in complex with a bisubstrate analogue (BA4)

Summary for 6QDX

• Entry DOI: 10.2210/pdb6qdx/pdb
• Descriptor: Ribosomal RNA large subunit methyltransferase J, (2~{S})-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[3-[[9-[(2~{S},3~{R},4~{S},5~{S})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]propyl]amino]-2-azanyl-butanoic acid (3 entities in total)
• Functional Keywords: rna mtases, methyltransferase, m6a, transition state analogue, inhibitor, rna binding, trmk, rlmj, m1a, structure., transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 4
• Total formula weight: 131786.48

Authors

Oerum, S.,Catala, M.,Atdjian, C.,Brachet, F.,Ponchon, L.,Barraud, P.,Iannazzo, L.,Droogmans, L.,Braud, E.,Etheve-Quelquejeu, M.,Tisne, C. (deposition date: 2019-01-03, release date: 2019-03-27, Last modification date: 2024-01-24)

• Primary citation: Oerum, S.,Catala, M.,Atdjian, C.,Brachet, F.,Ponchon, L.,Barraud, P.,Iannazzo, L.,Droogmans, L.,Braud, E.,Etheve-Quelquejeu, M.,Tisne, C.; Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites.; Rna Biol., 16:798-808, 2019; PubMed: 30879411; DOI: 10.1080/15476286.2019.1589360

Experimental method

X-RAY DIFFRACTION (2.1 Å)