6QE0

Structure of E.coli RlmJ in complex with a bisubstrate analogue (BA2)

Summary for 6QE0

Entry DOI	10.2210/pdb6qe0/pdb
Related	6QDX
Descriptor	Ribosomal RNA large subunit methyltransferase J, (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[[9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-6-yl]amino]ethyl]amino]-2-azanyl-butanoic acid (3 entities in total)
Functional Keywords	rna mtases, methyltransferase, m6a, transition state analogue, inhibitor, rna binding, trmk, rlmj, m1a, structure., transferase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	32932.59
Authors	Oerum, S.,Catala, M.,Atdjian, C.,Brachet, F.,Ponchon, L.,Barraud, P.,Iannazzo, L.,Droogmans, L.,Braud, E.,Etheve-Quelquejeu, M.,Tisne, C. (deposition date: 2019-01-03, release date: 2019-03-27, Last modification date: 2024-01-24)
Primary citation	Oerum, S.,Catala, M.,Atdjian, C.,Brachet, F.,Ponchon, L.,Barraud, P.,Iannazzo, L.,Droogmans, L.,Braud, E.,Etheve-Quelquejeu, M.,Tisne, C. Bisubstrate analogues as structural tools to investigate m6A methyltransferase active sites. Rna Biol., 16:798-808, 2019 Cited by PubMed: 30879411 DOI: 10.1080/15476286.2019.1589360 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.394 Å)

Structure validation