6B1N
 
 | |
6B9E
 | |
6B1I
 | |
6B9D
 | | Human ATL1 mutant - R77A bound to GDP | | 分子名称: | Atlastin-1, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | O'Donnell, J.P, Sondermann, H. | | 登録日 | 2017-10-10 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
J. Biol. Chem., 293, 2018
|
|
6B1M
 | |
6B9F
 | |
6B9G
 | | human ATL1 GTPase domain bound to GDP | | 分子名称: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | O'Donnell, J.P, Sondermann, H. | | 登録日 | 2017-10-10 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A hereditary spastic paraplegia-associated atlastin variant exhibits defective allosteric coupling in the catalytic core.
J. Biol. Chem., 293, 2018
|
|
5VGR
 | | Human Atlastin-3, GDP-bound | | 分子名称: | Atlastin-3, GUANOSINE-5'-DIPHOSPHATE | | 著者 | O'Donnell, J.P, Sondermann, H. | | 登録日 | 2017-04-11 | | 公開日 | 2017-05-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | | 主引用文献 | Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin.
Structure, 25, 2017
|
|
6Z3W
 | | Human ER membrane protein complex | | 分子名称: | ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1,ER membrane protein complex subunit 1, ER membrane protein complex subunit 10, ER membrane protein complex subunit 2, ... | | 著者 | Hegde, R.S, O'Donnell, J.P. | | 登録日 | 2020-05-22 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (6.4 Å) | | 主引用文献 | The architecture of EMC reveals a path for membrane protein insertion.
Elife, 9, 2020
|
|
6XJO
 | |
6XJN
 | |
6Y4L
 | |
4IDN
 | | Human atlastin-1 1-446, C-his6, GppNHp | | 分子名称: | Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
|
|
4IDO
 | | human atlastin-1 1-446, C-his6, GDPAlF4- | | 分子名称: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
|
|
4IDP
 | | human atlastin-1 1-446, N440T, GppNHp | | 分子名称: | Atlastin-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.587 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
|
|
4IDQ
 | | human atlastin-1 1-446, N440T, GDPAlF4- | | 分子名称: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, HEXAETHYLENE GLYCOL, ... | | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | | 登録日 | 2012-12-12 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin.
Embo J., 32, 2013
|
|
7JWL
 | | Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462 | | 分子名称: | CHLORIDE ION, ETX0462 (Bound form), Peptidoglycan D,D-transpeptidase FtsI | | 著者 | Mayclin, S.J, Abendroth, J, Horanyi, P.S, Sylvester, M, Wu, X, Shapiro, A, Moussa, S, Durand-Reville, T.F. | | 登録日 | 2020-08-25 | | 公開日 | 2021-05-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Rational design of a new antibiotic class for drug-resistant infections.
Nature, 597, 2021
|
|
7K99
 | | Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 | | 分子名称: | (hydroxy{(1S)-1-(methylsulfanyl)-2-[5-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)-1H-benzotriazol-1-yl]ethyl}amino)methanol, GLYCEROL, SULFATE ION, ... | | 著者 | Sacco, M, Chen, Y. | | 登録日 | 2020-09-28 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
Bioorg.Med.Chem., 28, 2020
|
|
7K9A
 | | Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, N-hydroxy-N-[(1R)-2-{5-[(4-{[2-(hydroxymethyl)-1H-imidazol-1-yl]methyl}phenyl)ethynyl]-1H-benzotriazol-1-yl}-1-(methylsulfanyl)ethyl]formamide, ... | | 著者 | Sacco, M, Chen, Y. | | 登録日 | 2020-09-29 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
Bioorg.Med.Chem., 28, 2020
|
|
6VHS
 | | Crystal structure of CTX-M-14 in complex with beta-lactamase inhibitor ETX1317 | | 分子名称: | (2R)-({[(3R,6S)-6-carbamoyl-1-formyl-4-methyl-1,2,3,6-tetrahydropyridin-3-yl]amino}oxy)(fluoro)acetic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | Sacco, M.D, Chen, Y. | | 登録日 | 2020-01-10 | | 公開日 | 2020-08-26 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | | 主引用文献 | Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine beta-Lactamases.
J.Med.Chem., 63, 2020
|
|
