6PXF
| Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution | 分子名称: | 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonic acid, Cathepsin K | 著者 | Law, S, Aguda, A.H, Nguyen, N.T, Brayer, G.D, Bromme, D. | 登録日 | 2019-07-25 | 公開日 | 2020-07-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution To Be Published
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5T6U
| Crystal structure of mouse cathepsin K at 2.9 Angstroms resolution. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin K, SULFATE ION | 著者 | Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D. | 登録日 | 2016-09-01 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Biochem. J., 474, 2017
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5TDI
| Crystal structure of Cathepsin K with a covalently-linked inhibitor at 1.4 Angstrom resolution. | 分子名称: | 4-fluoro-N-{1-[(Z)-iminomethyl]cyclopropyl}-N~2~-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl }-L-leucinamide, Cathepsin K | 著者 | Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D. | 登録日 | 2016-09-19 | 公開日 | 2017-01-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Biochem. J., 474, 2017
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6ASH
| Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution | 分子名称: | 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, Cathepsin K | 著者 | Law, S, Aguda, A, Nguyen, N, Brayer, G, Bromme, D. | 登録日 | 2017-08-24 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.423 Å) | 主引用文献 | Crystal structure of human Cathepsin K with a non-active site inhibitor at 1.42 Angstrom resolution. To Be Published
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6BKI
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5TUN
| Crystal structure of uninhibited human Cathepsin K at 1.62 Angstrom resolution | 分子名称: | Cathepsin K | 著者 | Aguda, A.H, Kruglyak, N, Nguyen, N.T, Law, S, Bromme, D, Brayer, G.D. | 登録日 | 2016-11-06 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib. Biochem. J., 474, 2017
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2UZR
| A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K) | 分子名称: | RAC-alpha serine/threonine-protein kinase | 著者 | Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E. | 登録日 | 2007-05-01 | 公開日 | 2007-07-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature, 448, 2007
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2UZS
| A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K) | 分子名称: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-alpha serine/threonine-protein kinase | 著者 | Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E. | 登録日 | 2007-05-01 | 公開日 | 2007-07-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature, 448, 2007
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7ZOA
| cryo-EM structure of CGT ABC transporter in presence of CBG substrate | 分子名称: | Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, Cyclooctadecakis-(1-2)-(beta-D-glucopyranose) | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | 登録日 | 2022-04-24 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella. Nat.Struct.Mol.Biol., 29, 2022
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7ZO8
| cryo-EM structure of CGT ABC transporter in nanodisc apo state | 分子名称: | Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, DIUNDECYL PHOSPHATIDYL CHOLINE | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | 登録日 | 2022-04-24 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella. Nat.Struct.Mol.Biol., 29, 2022
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7ZO9
| cryo-EM structure of CGT ABC transporter in vanadate trapped state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, VANADATE ION | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | 登録日 | 2022-04-24 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella. Nat.Struct.Mol.Biol., 29, 2022
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7ZNU
| cryo-EM structure of CGT ABC transporter in detergent micelle | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Beta-(1-->2)glucan export ATP-binding/permease protein NdvA, VANADATE ION | 著者 | Jaroslaw, S, Dong, C.N, Frank, L, Na, W, Renato, Z, Seunho, J, Henning, S, Christoph, D. | 登録日 | 2022-04-22 | 公開日 | 2022-12-07 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Mechanism of cyclic beta-glucan export by ABC transporter Cgt of Brucella. Nat.Struct.Mol.Biol., 29, 2022
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4YV8
| Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal | 分子名称: | Cathepsin K, Lichostatinal, SULFATE ION | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2015-03-19 | 公開日 | 2016-05-04 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
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4YVA
| Cathepsin K co-crystallized with actinomycetes extract | 分子名称: | Cathepsin K, SULFATE ION | 著者 | Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. | 登録日 | 2015-03-19 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
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8W2F
| Plasmodium falciparum 20S proteasome bound to an inhibitor | 分子名称: | (3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide, Proteasome endopeptidase complex, Proteasome subunit alpha type, ... | 著者 | Han, Y, Deng, X, Ray, S, Chen, Z, Phillips, M. | 登録日 | 2024-02-20 | 公開日 | 2024-07-31 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria. Cell Chem Biol, 31, 2024
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3LEI
| Lectin Domain of Lectinolysin complexed with Fucose | 分子名称: | CALCIUM ION, NICKEL (II) ION, Platelet aggregation factor Sm-hPAF, ... | 著者 | Feil, S.C. | 登録日 | 2010-01-14 | 公開日 | 2010-12-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure, 20, 2012
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3LE0
| Lectin Domain of Lectinolysin complexed with Glycerol | 分子名称: | CALCIUM ION, GLYCEROL, NICKEL (II) ION, ... | 著者 | Feil, S.C. | 登録日 | 2010-01-13 | 公開日 | 2010-12-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure, 20, 2012
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3LEG
| Lectin Domain of Lectinolysin complexed with Lewis Y Antigen | 分子名称: | CALCIUM ION, NICKEL (II) ION, Platelet aggregation factor Sm-hPAF, ... | 著者 | Feil, S.C. | 登録日 | 2010-01-14 | 公開日 | 2010-12-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure, 20, 2012
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3LEK
| Lectin Domain of Lectinolysin complexed with Lewis B Antigen | 分子名称: | CALCIUM ION, NICKEL (II) ION, Platelet aggregation factor Sm-hPAF, ... | 著者 | Feil, S.C. | 登録日 | 2010-01-15 | 公開日 | 2010-12-29 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure, 20, 2012
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5Z6D
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5Z6E
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5HT8
| Crystal structure of clostrillin double mutant (S17H,S19H) in complex with nickel | 分子名称: | Beta and gamma crystallin, NICKEL (II) ION | 著者 | Jamkhindikar, A, Srivastava, S.S, Sankaranarayanan, R. | 登録日 | 2016-01-26 | 公開日 | 2017-02-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | A Transition Metal-Binding, Trimeric beta gamma-Crystallin from Methane-Producing Thermophilic Archaea, Methanosaeta thermophila Biochemistry, 56, 2017
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5HT7
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