8W2F

Plasmodium falciparum 20S proteasome bound to an inhibitor

This is a non-PDB format compatible entry.

Summary for 8W2F

• Entry DOI: 10.2210/pdb8w2f/pdb
• EMDB information: 43746
• Descriptor: Proteasome endopeptidase complex, Proteasome subunit beta, Proteasome subunit beta type, ... (15 entities in total)
• Functional Keywords: malaria, plasmodium falciparum, proteasome, drug discovery, cytosolic protein, cytosolic protein-inhibitor complex, cytosolic protein/inhibitor
• Biological source: Plasmodium falciparum 3D7; More
• Total number of polymer chains: 28
• Total formula weight: 767152.69

Authors

Han, Y.,Deng, X.,Ray, S.,Chen, Z.,Phillips, M. (deposition date: 2024-02-20, release date: 2024-07-31)

• Primary citation: Lawong, A.,Gahalawat, S.; Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria; Cell Chem Biol, 2024

Experimental method

ELECTRON MICROSCOPY (3.1 Å)