8W2F

Plasmodium falciparum 20S proteasome bound to an inhibitor

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O	Proteasome endopeptidase complex	polymer	260	29531.7	2	UniProt (Q8IAR3) In PDB	Plasmodium falciparum 3D7
2	B, P	Proteasome endopeptidase complex	polymer	235	26556.4	2	UniProt (C6KST3) In PDB	Plasmodium falciparum 3D7
3	C, Q	Proteasome subunit alpha type	polymer	242	27443.0	2	UniProt (Q8IDG3) In PDB	Plasmodium falciparum 3D7
4	D, R	Proteasome subunit alpha type	polymer	241	27263.3	2	UniProt (Q8IDG2) In PDB	Plasmodium falciparum 3D7
5	E, S	Proteasome subunit alpha type	polymer	256	28417.4	2	UniProt (Q8IBI3) In PDB	Plasmodium falciparum 3D7
6	F, T	Proteasome endopeptidase complex	polymer	254	28871.7	2	UniProt (Q8IK90) In PDB	Plasmodium falciparum 3D7
7	G, U	Proteasome subunit alpha type-3, putative	polymer	252	29324.3	2	UniProt (O77396) In PDB	Plasmodium falciparum 3D7
8	H, V	Proteasome subunit beta type-6, putative	polymer	252	29143.9	2	UniProt (Q8I0U7) In PDB	Plasmodium falciparum 3D7
9	I, W	Proteasome subunit beta	polymer	229	25104.9	2	UniProt (Q8I6T3) In PDB	Plasmodium falciparum 3D7
10	J, X	Proteasome subunit beta	polymer	218	24533.1	2	UniProt (Q8I261) In PDB	Plasmodium falciparum 3D7
11	K, Y	Proteasome subunit beta	polymer	195	22889.1	2	UniProt (Q8IKC9) In PDB	Plasmodium falciparum 3D7
12	L, Z	Proteasome subunit beta type	polymer	211	23620.6	2	UniProt (Q8IJT1) In PDB	Plasmodium falciparum 3D7
13	N, b	Proteasome subunit beta	polymer	284	33155.2	2	UniProt (Q7K6A9) In PDB	Plasmodium falciparum 3D7
14	M, a	Proteasome subunit beta	polymer	240	27301.2	2	UniProt (A0A5K1K7U1) In PDB	Plasmodium falciparum 3D7
15	M, a	(3S)-1-[(2-fluoroethoxy)acetyl]-N-{[(4P)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide	non-polymer		420.5	2	Chemie (A1AE6)

Sequence modifications

N, b: 1 - 265 (UniProt: Q7K6A9)

PDB	External Database	Details
Gly 266	-	expression tag
Ser 267	-	expression tag
Gly 268	-	expression tag
Ser 269	-	expression tag
Glu 270	-	expression tag
Asn 271	-	expression tag
Leu 272	-	expression tag
Tyr 273	-	expression tag
Phe 274	-	expression tag
Gln 275	-	expression tag
Gly 276	-	expression tag
His 277	-	expression tag
His 278	-	expression tag
His 279	-	expression tag
His 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	766311.7
Non-Polymers*	Number of molecules	2
	Total formula weight	841.0
All*	Total formula weight	767152.7

*Water molecules are not included.