4HON
 
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4HOO
 | | Crystal structure of human JMJD2D/KDM4D apoenzyme | | 分子名称: | ACETATE ION, Lysine-specific demethylase 4D, NICKEL (II) ION, ... | | 著者 | Krishnan, S, Trievel, R.C. | | 登録日 | 2012-10-22 | | 公開日 | 2012-11-21 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | | 主引用文献 | Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases.
Structure, 21, 2013
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8U5Y
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8U61
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5XEE
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5XE4
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4D9T
 | | Rsk2 C-terminal Kinase Domain with inhibitor (E)-methyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate | | 分子名称: | Ribosomal protein S6 kinase alpha-3, SODIUM ION, methyl (2S)-3-{4-amino-7-[(1E)-3-hydroxyprop-1-en-1-yl]-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-2-cyanopropanoate | | 著者 | Serafimova, I.M, Pufall, M.A, Krishnan, S, Duda, K, Cohen, M.S, Maglathlin, R.L, McFarland, J.M, Miller, R.M, Frodin, M, Taunton, J. | | 登録日 | 2012-01-12 | | 公開日 | 2012-04-25 | | 最終更新日 | 2012-05-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
Nat.Chem.Biol., 8, 2012
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4D9U
 | | Rsk2 C-terminal Kinase Domain, (E)-tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate | | 分子名称: | Ribosomal protein S6 kinase alpha-3, SODIUM ION, tert-butyl (2S)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanopropanoate | | 著者 | Serafimova, I.M, Pufall, M.A, Krishnan, S, Duda, K, Cohen, M.S, Maglathlin, R.L, McFarland, J.M, Miller, R.M, Frodin, M, Taunton, J. | | 登録日 | 2012-01-12 | | 公開日 | 2012-04-11 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles.
Nat.Chem.Biol., 8, 2012
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4JG6
 | | RSK2 CTD bound to 2-cyano-3-(1H-indazol-5-yl)acrylamide | | 分子名称: | (2S)-2-cyano-3-(1H-indazol-5-yl)propanamide, Ribosomal protein S6 kinase alpha-3, SODIUM ION | | 著者 | Miller, R.M, Paavilainen, V.O, Krishnan, S, Serafimova, I.M, Taunton, J. | | 登録日 | 2013-02-28 | | 公開日 | 2013-04-10 | | 最終更新日 | 2013-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
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4JG7
 | | Structure of RSK2 CTD bound to 3-(3-(1H-pyrrolo[2,3-b]pyridine-3-carbonyl)phenyl)-2-cyanoacrylamide | | 分子名称: | (2R)-2-cyano-3-[3-(1H-pyrrolo[2,3-b]pyridin-3-ylcarbonyl)phenyl]propanamide, Ribosomal protein S6 kinase alpha-3, SODIUM ION | | 著者 | Miller, R.M, Paavilainen, V.O, Krishnan, S, Serafimova, I.M, Taunton, J. | | 登録日 | 2013-02-28 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.0002 Å) | | 主引用文献 | Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
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4JG8
 | | Structure of RSK2 T493M CTD mutant bound to 2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide | | 分子名称: | (2S)-2-cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]propanamide, Ribosomal protein S6 kinase alpha-3 | | 著者 | Miller, R.M, Paavilainen, V.O, Krishnan, S, Serafimova, I.M, Taunton, J. | | 登録日 | 2013-02-28 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.1002 Å) | | 主引用文献 | Electrophilic fragment-based design of reversible covalent kinase inhibitors.
J.Am.Chem.Soc., 135, 2013
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8S9W
 | | Murine S100A7/S100A15 in presence of calcium | | 分子名称: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | | 著者 | Harrison, S.A, Naretto, A, Balakrishnan, S, Chazin, W.J. | | 登録日 | 2023-03-30 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Comparative analysis of the physical properties of murine and human S100A7: Insight into why zinc piracy is mediated by human but not murine S100A7.
J.Biol.Chem., 299, 2023
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4MAO
 | | RSK2 T493M C-Terminal Kinase Domain in Complex with RMM58 | | 分子名称: | (2Z)-2-(1H-1,2,4-triazol-1-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enenitrile, Ribosomal protein S6 kinase alpha-3, SODIUM ION | | 著者 | Miller, R.M, Taunton, J. | | 登録日 | 2013-08-16 | | 公開日 | 2014-10-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
J.Am.Chem.Soc., 136, 2014
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6VWV
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6VWT
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1S6P
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8P4X
 | | FAD_ox bound dark state structure of PdLCry | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, Putative light-receptive cryptochrome (Fragment) | | 著者 | Behrmann, E, Behrmann, H. | | 登録日 | 2023-05-23 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | A marine cryptochrome with an inverse photo-oligomerization mechanism.
Nat Commun, 14, 2023
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6OCE
 | | Structure of the rice hyperosmolality-gated ion channel OSCA1.2 | | 分子名称: | stress-gated cation channel 1.2 | | 著者 | Maity, K, Heumann, J.M, McGrath, A.P, Chang, G, Stowell, M.H. | | 登録日 | 2019-03-23 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Cryo-EM structure of OSCA1.2 fromOryza sativaelucidates the mechanical basis of potential membrane hyperosmolality gating.
Proc.Natl.Acad.Sci.USA, 116, 2019
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7Y0D
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4GJY
 | | JMJD5 in complex with N-Oxalylglycine | | 分子名称: | COBALT (II) ION, JmjC domain-containing protein 5, N-OXALYLGLYCINE | | 著者 | Del Rizzo, P.A, Trievel, R.C. | | 登録日 | 2012-08-10 | | 公開日 | 2012-09-05 | | 最終更新日 | 2012-11-14 | | 実験手法 | X-RAY DIFFRACTION (1.2492 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Mol.Cell.Biol., 32, 2012
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4GJZ
 | | JMJD5 in complex with 2-oxoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, BETA-MERCAPTOETHANOL, COBALT (II) ION, ... | | 著者 | Del Rizzo, P.A, Trievel, R.C. | | 登録日 | 2012-08-10 | | 公開日 | 2012-09-05 | | 最終更新日 | 2012-11-14 | | 実験手法 | X-RAY DIFFRACTION (1.0481 Å) | | 主引用文献 | Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function.
Mol.Cell.Biol., 32, 2012
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4LV3
 | | AmpC beta-lactamase in complex with (3,5-di-tert-butylphenyl) boronic acid | | 分子名称: | (3,5-di-tert-butylphenyl)boronic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | London, N, Eidam, O, Shoichet, B.K. | | 登録日 | 2013-07-25 | | 公開日 | 2014-07-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Covalent docking of large libraries for the discovery of chemical probes.
Nat.Chem.Biol., 10, 2014
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4M8T
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4LV0
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4LV2
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