6EO1
| The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined) | 分子名称: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | 著者 | Kowal, J, Biyani, N, Chami, M, Scherer, S, Rzepiela, A, Baumgartner, P, Upadhyay, V, Nimigean, C, Stahlberg, H. | 登録日 | 2017-10-08 | 公開日 | 2017-12-27 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (4.5 Å) | 主引用文献 | High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer. Structure, 26, 2018
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4CHW
| The electron crystallography structure of the cAMP-free potassium channel MloK1 | 分子名称: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | 著者 | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | 登録日 | 2013-12-04 | 公開日 | 2014-01-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (7 Å) | 主引用文献 | Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1. Nat Commun, 5, 2014
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4CHV
| The electron crystallography structure of the cAMP-bound potassium channel MloK1 | 分子名称: | CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION | 著者 | Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H. | 登録日 | 2013-12-04 | 公開日 | 2014-01-15 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (7 Å) | 主引用文献 | Ligand-Induced Structural Changes in the Cyclic Nucleotide-Modulated Potassium Channel Mlok1 Nat.Commun., 5, 2014
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7NEZ
| Structure of topotecan-bound ABCG2 | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | 著者 | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | 登録日 | 2021-02-05 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NFD
| Structure of mitoxantrone-bound ABCG2 | 分子名称: | 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ... | 著者 | Kowal, J, Locher, K, Ni, D, Stahlberg, H. | 登録日 | 2021-02-06 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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7NEQ
| Structure of tariquidar-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Kowal, J, Locher, K. | 登録日 | 2021-02-04 | 公開日 | 2021-04-21 | 最終更新日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2. J.Mol.Biol., 433, 2021
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6EZN
| Cryo-EM structure of the yeast oligosaccharyltransferase (OST) complex | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wild, R, Kowal, J, Eyring, J, Ngwa, E.M, Aebi, M, Locher, K.P. | 登録日 | 2017-11-16 | 公開日 | 2018-01-17 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. Nat Commun, 13, 2022
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6I9D
| MloK1 consensus structure from single particle analysis of 2D crystals | 分子名称: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | 著者 | Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H. | 登録日 | 2018-11-23 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM. Nat Commun, 10, 2019
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6IAX
| MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation) | 分子名称: | Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION | 著者 | Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H. | 登録日 | 2018-11-27 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM. Nat Commun, 10, 2019
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6ETI
| Structure of inhibitor-bound ABCG2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ... | 著者 | Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P. | 登録日 | 2017-10-26 | 公開日 | 2018-04-11 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25, 2018
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7PHP
| Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-18 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PIJ
| Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-20 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7PHQ
| Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM | 分子名称: | Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ... | 著者 | Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2021-08-18 | 公開日 | 2021-09-01 | 最終更新日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (8.45 Å) | 主引用文献 | Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins. Proc.Natl.Acad.Sci.USA, 118, 2021
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7OCI
| Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wild, R, Neuhaus, J.D, Eyring, J, Irobalieva, R.N, Kowal, J, Lin, C.W, Locher, K.P, Aebi, M. | 登録日 | 2021-04-27 | 公開日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases. Glycobiology, 31, 2021
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5NJG
| Structure of an ABC transporter: part of the structure that could be built de novo | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | 著者 | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | 登録日 | 2017-03-28 | 公開日 | 2017-06-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
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7OJ8
| ABCG2 E1S turnover-2 state | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ... | 著者 | Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-14 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJH
| ABCG2 topotecan turnover-1 state | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-15 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OJI
| ABCG2 topotecan turnover-2 state | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-16 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
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7OZ1
| Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Skarda, L, Kowal, J, Locher, K.P. | 登録日 | 2021-06-25 | 公開日 | 2021-09-22 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of the Human Cholesterol Transporter ABCG1. J.Mol.Biol., 433, 2021
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5NJ3
| Structure of an ABC transporter: complete structure | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ... | 著者 | Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P. | 登録日 | 2017-03-28 | 公開日 | 2017-06-07 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structure of the human multidrug transporter ABCG2. Nature, 546, 2017
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2N5E
| The 3D solution structure of discoidal high-density lipoprotein particles | 分子名称: | Apolipoprotein A-I | 著者 | Bibow, S, Polyhach, Y, Eichmann, C, Chi, C.N, Kowal, J, Stahlberg, H, Jeschke, G, Guentert, P, Riek, R. | 登録日 | 2015-07-15 | 公開日 | 2016-12-21 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I. Nat.Struct.Mol.Biol., 24, 2017
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8PG0
| Human OATP1B3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ... | 著者 | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2023-06-17 | 公開日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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8PHW
| Human OATP1B1 | 分子名称: | CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ... | 著者 | Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P. | 登録日 | 2023-06-20 | 公開日 | 2023-09-27 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of human drug transporters OATP1B1 and OATP1B3. Nat Commun, 14, 2023
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8PM6
| Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs | 分子名称: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL | 著者 | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | 登録日 | 2023-06-28 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
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8PMJ
| Vanadate-trapped BSEP in nanodiscs | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ... | 著者 | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | 登録日 | 2023-06-28 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
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