1VAX
| Crystal Structure of Uricase from Arthrobacter globiformis | 分子名称: | Uric acid oxidase | 著者 | Hossain, M.T, Suzuki, K, Yamamoto, T, Imamura, S, Sekiguchi, T, Takenaka, A. | 登録日 | 2004-02-19 | 公開日 | 2005-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Crystal Structure of Uricase from Arthrobacter globiformis To be Published
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1V5G
| Crystal Structure of the Reaction Intermediate between Pyruvate oxidase containing FAD and TPP, and Substrate Pyruvate | 分子名称: | 2-ACETYL-THIAMINE DIPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... | 著者 | Hossain, M.T, Suzuki, K, Yamamoto, T, Imamura, S, Sekiguchi, T, Takenaka, A. | 登録日 | 2003-11-22 | 公開日 | 2005-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | The structures of pyruvate oxidase from Aerococcus viridans with cofactors and with a reaction intermediate reveal the flexibility of the active-site tunnel for catalysis. Acta Crystallogr.,Sect.F, 63, 2007
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1V5F
| Crystal Structure of Pyruvate oxidase complexed with FAD and TPP, from Aerococcus viridans | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, Pyruvate oxidase, ... | 著者 | Hossain, M.T, Suzuki, K, Yamamoto, T, Imamura, S, Sekiguchi, T, Takenaka, A. | 登録日 | 2003-11-22 | 公開日 | 2005-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The structures of pyruvate oxidase from Aerococcus viridans with cofactors and with a reaction intermediate reveal the flexibility of the active-site tunnel for catalysis. Acta Crystallogr.,Sect.F, 63, 2007
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2DJI
| Crystal Structure of Pyruvate Oxidase from Aerococcus viridans containing FAD | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Pyruvate oxidase, SULFATE ION | 著者 | Juan, E.C.M, Hossain, M.T, Suzuki, K, Yamamoto, T, Imamura, S, Sekiguchi, T, Takenaka, A. | 登録日 | 2006-04-03 | 公開日 | 2007-05-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The structures of pyruvate oxidase from Aerococcus viridans with cofactors and with a reaction intermediate reveal the flexibility of the active-site tunnel for catalysis. Acta Crystallogr.,Sect.F, 63, 2007
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1V5E
| Crystal Structure of Pyruvate oxidase containing FAD, from Aerococcus viridans | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Pyruvate oxidase, SULFATE ION | 著者 | Hossain, M.T, Suzuki, K, Yamamoto, T, Imamura, S, Sekiguchi, T, Takenaka, A. | 登録日 | 2003-11-22 | 公開日 | 2005-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of Pyruvate oxidase containing FAD, from Aerococcus viridans To be Published
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1VAY
| Crystal Structure of Uricase from Arthrobacter globiformis with inhibitor 8-azaxanthine | 分子名称: | 8-AZAXANTHINE, Uric acid oxidase | 著者 | Hossain, M.T, Suzuki, K, Yamamoto, T, Imamura, S, Sekiguchi, T, Takenaka, A. | 登録日 | 2004-02-19 | 公開日 | 2005-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Crystal Structure of Uricase from Arthrobacter Globiformis Complexed with an inhibitor 8-Azaxanthine To be Published
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3VW8
| Crystal structure of human c-Met kinase domain with its inhibitor | 分子名称: | CHLORIDE ION, Hepatocyte growth factor receptor, N-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | 著者 | Matsumoto, S, Miyamoto, N, Hirayama, T, Oki, H, Okada, K, Tawada, M, Iwata, H, Miki, H, Nakamura, K, Hori, A, Imamura, S. | 登録日 | 2012-08-08 | 公開日 | 2013-08-14 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-based design, synthesis, and evaluation of imidazo[1,2-b]pyridazine and imidazo[1,2-a]pyridine derivatives as novel dual c-Met and VEGFR2 kinase inhibitors. Bioorg.Med.Chem., 21, 2013
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3VDR
| Crystal structure of D-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate D-3-hydroxybutyrate and NAD(+) | 分子名称: | (3R)-3-hydroxybutanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ACETOACETIC ACID, ... | 著者 | Hoque, M.M, Shimizu, S, Juan, E.C.M, Sato, Y, Hossain, M.T, Yamamoto, T, Imamura, S, Amano, H, Suzuki, K, Sekiguchi, T, Tsunoda, M, Takenaka, A. | 登録日 | 2012-01-06 | 公開日 | 2012-02-08 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of D-3-hydroxybutyrate dehydrogenase prepared in the presence of the substrate D-3-hydroxybutyrate and NAD+. Acta Crystallogr.,Sect.F, 65, 2009
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3VHK
| Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder | 分子名称: | 1,2-ETHANEDIOL, Vascular endothelial growth factor receptor 2, {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol | 著者 | Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. | 登録日 | 2011-08-25 | 公開日 | 2012-09-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3, 2012
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3VID
| Crystal structure of human VEGFR2 kinase domain with Compound A. | 分子名称: | 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole, Vascular endothelial growth factor receptor 2 | 著者 | Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H. | 登録日 | 2011-09-29 | 公開日 | 2012-08-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases. ACS MED.CHEM.LETT., 3, 2012
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4AOF
| Selective small molecule inhibitor discovered by chemoproteomic assay platform reveals regulation of Th17 cell differentiation by PI3Kgamma | 分子名称: | N-[6-(5-methylsulfonylpyridin-3-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]ethanamide, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM | 著者 | Bergamini, G, Bell, K, Shimamura, S, Werner, T, Cansfield, A, Muller, K, Perrin, J, Rau, C, Ellard, K, Hopf, C, Doce, C, Leggate, D, Mangano, R, Mathieson, T, OMahony, A, Plavec, I, Rharbaoui, F, Reinhard, F, Savitski, M.M, Ramsden, N, Hirsch, E, Drewes, G, Rausch, O, Bantscheff, M, Neubauer, G. | 登録日 | 2012-03-26 | 公開日 | 2012-05-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A Selective Inhibitor Reveals Pi3Kgamma Dependence of T(H)17 Cell Differentiation. Nat.Chem.Biol., 8, 2012
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6WL6
| Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(2R)-1-AMINO-4-METHYLPENTAN-2-YL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE | 分子名称: | 6-[(2R)-1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one, Deoxyhypusine synthase | 著者 | Klein, M.G, Ambrus-Aikelin, G. | 登録日 | 2020-04-18 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. Acs Med.Chem.Lett., 11, 2020
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6P4V
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6PGR
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6WKZ
| Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(1R)-2-AMINO-1-PHENYLETHYL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE | 分子名称: | 6-[(1R)-2-amino-1-phenylethyl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one, Deoxyhypusine synthase | 著者 | Klein, M.G, Ambrus-Aikelin, G. | 登録日 | 2020-04-17 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. Acs Med.Chem.Lett., 11, 2020
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1LWB
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4HY4
| Crystal structure of cIAP1 BIR3 bound to T3170284 | 分子名称: | (3S,8aR)-2-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION | 著者 | Dougan, D.R, Mol, C.D, Snell, G.P. | 登録日 | 2012-11-12 | 公開日 | 2013-01-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.249 Å) | 主引用文献 | Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56, 2013
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4HY5
| Crystal structure of cIAP1 BIR3 bound to T3256336 | 分子名称: | (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide, Baculoviral IAP repeat-containing protein 2, ZINC ION | 著者 | Dougan, D.R, Snell, G.P. | 登録日 | 2012-11-13 | 公開日 | 2013-01-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.752 Å) | 主引用文献 | Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56, 2013
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4HY0
| Crystal structure of XIAP BIR3 with T3256336 | 分子名称: | (3S,7R,8aR)-2-{(2S)-2-(4,4-difluorocyclohexyl)-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]-7-ethoxyoctahydropyrrolo[1,2-a]pyrazine-3-carboxamide, E3 ubiquitin-protein ligase XIAP, ZINC ION | 著者 | Snell, G.S, Dougan, D.R. | 登録日 | 2012-11-12 | 公開日 | 2013-01-30 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic. J.Med.Chem., 56, 2013
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1IT4
| Solution structure of the prokaryotic Phospholipase A2 from Streptomyces violaceoruber | 分子名称: | CALCIUM ION, phospholipase A2 | 著者 | Ohtani, K, Sugiyama, M, Izuhara, M, Koike, T. | 登録日 | 2002-01-08 | 公開日 | 2002-09-04 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel prokaryotic phospholipase A2. Characterization, gene cloning, and solution structure. J.BIOL.CHEM., 277, 2002
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1IT5
| Solution structure of apo-type PLA2 from Streptomyces violaceruber A-2688. | 分子名称: | Phospholipase A2 | 著者 | Sugiyama, M, Ohtani, K, Izuhara, M, Koike, T. | 登録日 | 2002-01-09 | 公開日 | 2002-09-04 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel prokaryotic phospholipase A2. Characterization, gene cloning, and solution structure. J.Biol.Chem., 277, 2002
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2YZ7
| X-ray analyses of 3-hydroxybutyrate dehydrogenase from Alcaligenes faecalis | 分子名称: | CALCIUM ION, CHLORIDE ION, D-3-hydroxybutyrate dehydrogenase | 著者 | Hoque, M.M, Juan, E.C.M, Shimizu, S, Hossain, M.T, Takenaka, A. | 登録日 | 2007-05-04 | 公開日 | 2008-04-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | The structures of Alcaligenes faecalisD-3-hydroxybutyrate dehydrogenase before and after NAD(+) and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family. Acta Crystallogr.,Sect.D, 64, 2008
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3VDQ
| Crystal structure of alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate | 分子名称: | ACETATE ION, CALCIUM ION, CHLORIDE ION, ... | 著者 | Hoque, M.M, Shimizu, S, Hossain, M.T, Yamamoto, T, Suzuki, K, Takenaka, A. | 登録日 | 2012-01-06 | 公開日 | 2012-02-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family. Acta Crystallogr.,Sect.D, 64, 2008
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3VO3
| Crystal Structure of the Kinase domain of Human VEGFR2 with imidazo[1,2-b]pyridazine derivative | 分子名称: | 1,2-ETHANEDIOL, N-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide, Vascular endothelial growth factor receptor 2 | 著者 | Oki, H, Okada, K. | 登録日 | 2012-01-19 | 公開日 | 2013-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor Bioorg.Med.Chem., 21, 2013
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3VHE
| Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor. | 分子名称: | 1-{2-fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Vascular endothelial growth factor receptor 2 | 著者 | Oguro, Y, Miyamoto, N, Okada, K, Takagi, T, Iwata, H, Awazu, Y, Miki, H, Hori, A, Kamiyama, K, Imanura, S. | 登録日 | 2011-08-24 | 公開日 | 2011-11-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation. Bioorg.Med.Chem., 18, 2010
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