6PGR

Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-BROMO-N-(1H-INDOL-4-YL)-1-BENZOTHIOPHENE-2-CARBOXAMIDE

Summary for 6PGR

• Entry DOI: 10.2210/pdb6pgr/pdb
• Related: 5V15 5V4J
• Descriptor: Deoxyhypusine synthase, 6-bromo-N-(1H-indol-4-yl)-1-benzothiophene-2-carboxamide (3 entities in total)
• Functional Keywords: deoxyhypusine, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 83169.73

Authors

Klein, M.G.,Ambrus-Aikelin, G. (deposition date: 2019-06-24, release date: 2020-04-01, Last modification date: 2023-10-11)

• Primary citation: Tanaka, Y.,Kurasawa, O.,Yokota, A.,Klein, M.G.,Ono, K.,Saito, B.,Matsumoto, S.,Okaniwa, M.,Ambrus-Aikelin, G.,Morishita, D.,Kitazawa, S.,Uchiyama, N.,Ogawa, K.,Kimura, H.,Imamura, S.; Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase.; J.Med.Chem., 63:3215-3226, 2020; PubMed: 32142284; DOI: 10.1021/acs.jmedchem.9b01979

Experimental method

X-RAY DIFFRACTION (1.95 Å)