6WL6

Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(2R)-1-AMINO-4-METHYLPENTAN-2-YL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE

Summary for 6WL6

Entry DOI	10.2210/pdb6wl6/pdb
Related	5V15 5V2E 5V4J
Descriptor	Deoxyhypusine synthase, 6-[(2R)-1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one (3 entities in total)
Functional Keywords	deoxyhypusine, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	83086.15
Authors	Klein, M.G.,Ambrus-Aikelin, G. (deposition date: 2020-04-18, release date: 2020-08-19, Last modification date: 2023-10-18)
Primary citation	Tanaka, Y.,Kurasawa, O.,Yokota, A.,Klein, M.G.,Saito, B.,Matsumoto, S.,Okaniwa, M.,Ambrus-Aikelin, G.,Uchiyama, N.,Morishita, D.,Kimura, H.,Imamura, S. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. Acs Med.Chem.Lett., 11:1645-1652, 2020 Cited by PubMed: 34345355 DOI: 10.1021/acsmedchemlett.0c00331 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation