6WL6

Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(2R)-1-AMINO-4-METHYLPENTAN-2-YL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0008216	biological_process	spermidine metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
A	0016740	molecular_function	transferase activity
A	0034038	molecular_function	deoxyhypusine synthase activity
A	0042102	biological_process	positive regulation of T cell proliferation
A	0042593	biological_process	glucose homeostasis
A	0042802	molecular_function	identical protein binding
A	0046203	biological_process	spermidine catabolic process
A	0051604	biological_process	protein maturation
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0008216	biological_process	spermidine metabolic process
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
B	0016740	molecular_function	transferase activity
B	0034038	molecular_function	deoxyhypusine synthase activity
B	0042102	biological_process	positive regulation of T cell proliferation
B	0042593	biological_process	glucose homeostasis
B	0042802	molecular_function	identical protein binding
B	0046203	biological_process	spermidine catabolic process
B	0051604	biological_process	protein maturation

Functional Information from PDB Data

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9493264","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

Chain	Residue	Details
A	GLU137	electrostatic stabiliser

Chain	Residue	Details
B	GLU137	electrostatic stabiliser