6WL6

Cocomplex structure of Deoxyhypusine synthase with inhibitor 6-[(2R)-1-AMINO-4-METHYLPENTAN-2-YL]-3-(PYRIDIN-3-YL)-4H,5H,6H,7H-THIENO[2,3-C]PYRIDIN-7-ONE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Deoxyhypusine synthase	polymer	372	41213.6	2	UniProt (P49366) Pfam (PF01916)	Homo sapiens (Human)	DHS
2	C, D (A, B)	6-[(2R)-1-amino-4-methylpentan-2-yl]-3-(pyridin-3-yl)-5,6-dihydrothieno[2,3-c]pyridin-7(4H)-one	non-polymer		329.5	2	Chemie (91A)
3	E, F (A, B)	water	water		18.0	192	Chemie (HOH)

Sequence modifications

A, B: 1 - 369 (UniProt: P49366)

PDB	External Database	Details
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82427.2
Non-Polymers*	Number of molecules	2
	Total formula weight	658.9
All*	Total formula weight	83086.1

*Water molecules are not included.