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Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST
分子名称:	Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST
著者	Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D.
登録日	2022-06-01
公開日	2022-07-06
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (2.97 Å)
主引用文献	The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nat Commun, 13, 2022

4QQ5

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
分子名称:	Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide
著者	Huang, Z, Mohammadi, M.
登録日	2014-06-26
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.203 Å)
主引用文献	DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10, 2015

4QQJ

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain Harboring the V550L Gate-Keeper Mutation
分子名称:	Fibroblast growth factor receptor 4, SULFATE ION
著者	Huang, Z, Mohammadi, M.
登録日	2014-06-27
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.682 Å)
主引用文献	DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10, 2015

4QQT

Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain
分子名称:	Fibroblast growth factor receptor 4, SULFATE ION
著者	Huang, Z, Mohammadi, M.
登録日	2014-06-29
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.501 Å)
主引用文献	DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10, 2015

4QRC

Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib
分子名称:	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Fibroblast growth factor receptor 4, SULFATE ION
著者	Huang, Z, Mohammadi, M.
登録日	2014-06-30
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.901 Å)
主引用文献	DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10, 2015

5EG3

Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)
分子名称:	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
著者	Huang, Z, Li, X, Mohammadi, M.
登録日	2015-10-26
公開日	2016-02-03
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.606 Å)
主引用文献	Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma. Mol.Cell, 61, 2016

4K33

Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma
分子名称:	Fibroblast growth factor receptor 3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者	Huang, Z, Chen, H, Mohammadi, M.
登録日	2013-04-10
公開日	2013-09-11
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.3405 Å)
主引用文献	Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation. Structure, 21, 2013

8QAO

Crystal structure of TP901-1 CI-NTD89 repressor N-terminal domain
分子名称:	CI
著者	Huang, Z, Hamad, G.M, Lo Leggio, L, Varming, A.K.
登録日	2023-08-23
公開日	2024-02-28
最終更新日	2024-06-19
実験手法	X-RAY DIFFRACTION (1.29 Å)
主引用文献	CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus phi 13 bacteriophages. Microbiome Res Rep, 3, 2024

3DJA

Crystal Structure of cpaf solved with MAD
分子名称:	Protein CT_858
著者	Chai, J, Huang, Z.
登録日	2008-06-22
公開日	2009-01-13
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008

3DPN

Crystal Structure of cpaf s499a mutant
分子名称:	Protein CT_858
著者	Chai, J, Huang, Z.
登録日	2008-07-09
公開日	2009-01-13
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008

3DOR

Crystal Structure of mature CPAF
分子名称:	Protein CT_858, SULFATE ION
著者	Chai, J, Huang, Z.
登録日	2008-07-06
公開日	2009-01-13
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008

3DPM

Structure of mature CPAF complexed with lactacystin
分子名称:	N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)cysteine, Protein CT_858
著者	Chai, J, Huang, Z.
登録日	2008-07-09
公開日	2009-01-13
最終更新日	2023-11-01
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008

4R6V

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations
分子名称:	Fibroblast growth factor receptor 4, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide, SULFATE ION
著者	Huang, Z, Mohammadi, M.
登録日	2014-08-26
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.353 Å)
主引用文献	Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014

3CXB

Crystal Structure of sifa and skip
分子名称:	Pleckstrin homology domain-containing family M member 2, Protein sifA
著者	Huang, Z, Chai, J.
登録日	2008-04-24
公開日	2008-12-02
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation Cell Host Microbe, 4, 2008

3GCG

crystal structure of MAP and CDC42 complex
分子名称:	Cell division control protein 42 homolog, L0028 (Mitochondria associated protein)
著者	Chai, J, Huang, Z, Feng, Y, Wu, X.
登録日	2009-02-22
公開日	2009-07-21
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics Nat.Struct.Mol.Biol., 16, 2009

1Z7I

2'-Me-Se Derivitation of A-DNA Octamer G(UMSe)GTACAC
分子名称:	5'-D(GP(UMS)PGPTPAPCPAPC)-3', SPERMINE
著者	Huang, Z, Carrasco, N, Jiang, J.
登録日	2005-03-24
公開日	2005-04-05
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (1.28 Å)
主引用文献	Selenium derivatization of nucleic acids for crystallography. Nucleic Acids Res., 35, 2007

4QQC

Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
分子名称:	Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION
著者	Huang, Z, Mohammadi, M.
登録日	2014-06-27
公開日	2014-10-29
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014

7ZE9

Structure of an AA16 LPMO-like protein
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, COPPER (II) ION, ...
著者	Huang, Z, Banerjee, S, Muderspach, S.J, Sun, P, van Berkel, W.J.H, Kabel, M.A, Lo Leggio, L.
登録日	2022-03-30
公開日	2023-03-15
最終更新日	2024-05-01
実験手法	X-RAY DIFFRACTION (2.646 Å)
主引用文献	AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila. Acs Catalysis, 13, 2023

4J98

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.
分子名称:	Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者	Huang, Z, Chen, H, Mohammadi, M.
登録日	2013-02-15
公開日	2013-08-07
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.3067 Å)
主引用文献	Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations. Cell Rep, 4, 2013

5Y2F

Human SIRT6 in complex with allosteric activator MDL-801
分子名称:	5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ...
著者	Zhang, J, Huang, Z, Song, K.
登録日	2017-07-25
公開日	2018-11-07
最終更新日	2018-11-28
実験手法	X-RAY DIFFRACTION (2.53 Å)
主引用文献	Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol., 14, 2018

3BM0

Structure of DNA Octamer G(dUSe)G(5-SedU)ACAC
分子名称:	5'-D(GP(2'-Se-U)PGP(5-Se-U)PAPCPAPC)-3'
著者	Jiang, J, SHeng, J, Hassan, A.E, Huang, Z.
登録日	2007-12-11
公開日	2008-06-10
最終更新日	2024-02-21
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Synthesis and crystallographic analysis of 5-Se-thymidine DNAs. Org.Lett., 11, 2009

5W7O

2-Se-T4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant
分子名称:	DNA (5'-D(APTPGP(US3)PCPG)-3'), MAGNESIUM ION, RNA (5'-R(UPCPGPAPCPA)-3'), ...
著者	Fang, Z, Yang, F, Huang, Z.
登録日	2017-06-20
公開日	2017-06-28
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	2-Se-T-modified-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant To Be Published

5WJR

High resolution native hexamer DNA and RNA hybrid in complex with RNase H catalytic domain D132N mutant
分子名称:	DNA (5'-D(APTPGPTPCPG)-3'), MAGNESIUM ION, RNA (5'-R(UPCPGPAPCPA)-3'), ...
著者	Fang, Z, Huang, Z.
登録日	2017-07-24
公開日	2017-08-09
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023

8YE6

Cryo-EM structure of Cas9-sgRNA-A32 complex
分子名称:	A32, CRISPR-associated endonuclease Cas9/Csn1, RNA (92-MER)
著者	Zheng, J, Zhu, Y, Huang, Z.
登録日	2024-02-22
公開日	2024-09-11
実験手法	ELECTRON MICROSCOPY (2.95 Å)
主引用文献	Inhibition mechanisms of CRISPR-Cas9 by AcrIIA25.1 and AcrIIA32. Sci China Life Sci, 67, 2024

5WTI

Crystal structure of the CRISPR-associated protein in complex with crRNA and DNA
分子名称:	CRISPR-associated protein, DNA (28-MER), DNA (5'-D(PGPTPGPTPGPGPAPTPTPCPCPG)-3'), ...
著者	Wu, D, Guan, X, Zhu, Y, Huang, Z.
登録日	2016-12-13
公開日	2017-11-01
実験手法	X-RAY DIFFRACTION (2.682 Å)
主引用文献	Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA Cell Res., 27, 2017

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