7L8N
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4K33
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![BU of 4k33 by Molmil](/molmil-images/mine/4k33) | Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma | 分子名称: | Fibroblast growth factor receptor 3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Huang, Z, Chen, H, Mohammadi, M. | 登録日 | 2013-04-10 | 公開日 | 2013-09-11 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3405 Å) | 主引用文献 | Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation. Structure, 21, 2013
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8D3F
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![BU of 8d3f by Molmil](/molmil-images/mine/8d3f) | Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma protein TgIST | 分子名称: | Signal transducer and activator of transcription 1-alpha/beta,Inhibitor of STAT1-dependent transcription TgIST | 著者 | Huang, Z, Liu, H, Nix, J.C, Amarasinghe, G.K, Sibley, L.D. | 登録日 | 2022-06-01 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment. Nat Commun, 13, 2022
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4QRC
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4QQ5
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![BU of 4qq5 by Molmil](/molmil-images/mine/4qq5) | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations | 分子名称: | Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide | 著者 | Huang, Z, Mohammadi, M. | 登録日 | 2014-06-26 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10, 2015
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4QQJ
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4QQT
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5EG3
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![BU of 5eg3 by Molmil](/molmil-images/mine/5eg3) | Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma) | 分子名称: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ... | 著者 | Huang, Z, Li, X, Mohammadi, M. | 登録日 | 2015-10-26 | 公開日 | 2016-02-03 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.606 Å) | 主引用文献 | Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma. Mol.Cell, 61, 2016
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8QAO
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3DJA
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3DPN
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3DOR
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![BU of 3dor by Molmil](/molmil-images/mine/3dor) | Crystal Structure of mature CPAF | 分子名称: | Protein CT_858, SULFATE ION | 著者 | Chai, J, Huang, Z. | 登録日 | 2008-07-06 | 公開日 | 2009-01-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008
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3DPM
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![BU of 3dpm by Molmil](/molmil-images/mine/3dpm) | Structure of mature CPAF complexed with lactacystin | 分子名称: | N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)cysteine, Protein CT_858 | 著者 | Chai, J, Huang, Z. | 登録日 | 2008-07-09 | 公開日 | 2009-01-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008
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7ZE9
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![BU of 7ze9 by Molmil](/molmil-images/mine/7ze9) | Structure of an AA16 LPMO-like protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, COPPER (II) ION, ... | 著者 | Huang, Z, Banerjee, S, Muderspach, S.J, Sun, P, van Berkel, W.J.H, Kabel, M.A, Lo Leggio, L. | 登録日 | 2022-03-30 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.646 Å) | 主引用文献 | AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila. Acs Catalysis, 13, 2023
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3CXB
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![BU of 3cxb by Molmil](/molmil-images/mine/3cxb) | Crystal Structure of sifa and skip | 分子名称: | Pleckstrin homology domain-containing family M member 2, Protein sifA | 著者 | Huang, Z, Chai, J. | 登録日 | 2008-04-24 | 公開日 | 2008-12-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation Cell Host Microbe, 4, 2008
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3GCG
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![BU of 3gcg by Molmil](/molmil-images/mine/3gcg) | crystal structure of MAP and CDC42 complex | 分子名称: | Cell division control protein 42 homolog, L0028 (Mitochondria associated protein) | 著者 | Chai, J, Huang, Z, Feng, Y, Wu, X. | 登録日 | 2009-02-22 | 公開日 | 2009-07-21 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics Nat.Struct.Mol.Biol., 16, 2009
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1Z7I
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5Y2F
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![BU of 5y2f by Molmil](/molmil-images/mine/5y2f) | Human SIRT6 in complex with allosteric activator MDL-801 | 分子名称: | 5-[[3,5-bis(chloranyl)phenyl]sulfonylamino]-2-[(5-bromanyl-4-fluoranyl-2-methyl-phenyl)sulfamoyl]benzoic acid, 9-mer peptide QTARKSTGG, DI(HYDROXYETHYL)ETHER, ... | 著者 | Zhang, J, Huang, Z, Song, K. | 登録日 | 2017-07-25 | 公開日 | 2018-11-07 | 最終更新日 | 2018-11-28 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol., 14, 2018
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4QQC
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![BU of 4qqc by Molmil](/molmil-images/mine/4qqc) | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations | 分子名称: | Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION | 著者 | Huang, Z, Mohammadi, M. | 登録日 | 2014-06-27 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
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4R6V
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![BU of 4r6v by Molmil](/molmil-images/mine/4r6v) | Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations | 分子名称: | Fibroblast growth factor receptor 4, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide, SULFATE ION | 著者 | Huang, Z, Mohammadi, M. | 登録日 | 2014-08-26 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | 主引用文献 | Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
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4J98
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1HV4
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![BU of 1hv4 by Molmil](/molmil-images/mine/1hv4) | CRYSTAL STRUCTURE ANALYSIS OF BAR-HEAD GOOSE HEMOGLOBIN (DEOXY FORM) | 分子名称: | HEMOGLOBIN ALPHA-A CHAIN, HEMOGLOBIN BETA CHAIN, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Liang, Y, Hua, Z, Liang, X, Xu, Q, Lu, G. | 登録日 | 2001-01-07 | 公開日 | 2001-01-17 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The crystal structure of bar-headed goose hemoglobin in deoxy form: the allosteric mechanism of a hemoglobin species with high oxygen affinity. J.Mol.Biol., 313, 2001
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5W7N
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3LTU
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![BU of 3ltu by Molmil](/molmil-images/mine/3ltu) | 5-SeMe-dU containing DNA 8mer | 分子名称: | 5'-D(*GP*(UMS)P*GP*(T5S)P*AP*CP*AP*C)-3' | 著者 | Sheng, J, Hassan, A.E.A, Zhang, W, Gan, J, Huang, Z. | 登録日 | 2010-02-16 | 公開日 | 2010-03-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
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6X5D
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