3RI5
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![BU of 3ri5 by Molmil](/molmil-images/mine/3ri5) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and picrotoxin | 分子名称: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hibbs, R.E, Gouaux, E. | 登録日 | 2011-04-12 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature, 474, 2011
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3RHW
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![BU of 3rhw by Molmil](/molmil-images/mine/3rhw) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and ivermectin | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | 著者 | Hibbs, R.E, Gouaux, E. | 登録日 | 2011-04-12 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.26 Å) | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature, 474, 2011
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3RIF
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![BU of 3rif by Molmil](/molmil-images/mine/3rif) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and glutamate. | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | 著者 | Hibbs, R.E, Gouaux, E. | 登録日 | 2011-04-13 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.345 Å) | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature, 474, 2011
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3RIA
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![BU of 3ria by Molmil](/molmil-images/mine/3ria) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab, ivermectin and iodide. | 分子名称: | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ... | 著者 | Hibbs, R.E, Gouaux, E. | 登録日 | 2011-04-13 | 公開日 | 2011-05-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature, 474, 2011
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4TNW
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![BU of 4tnw by Molmil](/molmil-images/mine/4tnw) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab and POPC in a lipid-modulated conformation | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, ... | 著者 | Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E. | 登録日 | 2014-06-05 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature, 512, 2014
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4TNV
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![BU of 4tnv by Molmil](/molmil-images/mine/4tnv) | C. elegans glutamate-gated chloride channel (GluCl) in complex with Fab in a non-conducting conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Avermectin-sensitive glutamate-gated chloride channel GluCl alpha, CHLORIDE ION, ... | 著者 | Althoff, T, Hibbs, R.E, Banerjee, S, Gouaux, E. | 登録日 | 2014-06-05 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature, 512, 2014
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6D6U
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![BU of 6d6u by Molmil](/molmil-images/mine/6d6u) | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | 登録日 | 2018-04-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | 主引用文献 | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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6D6T
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![BU of 6d6t by Molmil](/molmil-images/mine/6d6t) | Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E. | 登録日 | 2018-04-22 | 公開日 | 2018-06-27 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.86 Å) | 主引用文献 | Structure of a human synaptic GABAAreceptor. Nature, 559, 2018
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8DD3
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![BU of 8dd3 by Molmil](/molmil-images/mine/8dd3) | |
8DD2
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![BU of 8dd2 by Molmil](/molmil-images/mine/8dd2) | |
5KXI
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![BU of 5kxi by Molmil](/molmil-images/mine/5kxi) | X-ray structure of the human Alpha4Beta2 nicotinic receptor | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Neuronal acetylcholine receptor subunit alpha-4, ... | 著者 | Morales-Perez, C.L, Noviello, C.M, Hibbs, R.E. | 登録日 | 2016-07-20 | 公開日 | 2016-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.941 Å) | 主引用文献 | X-ray structure of the human alpha 4 beta 2 nicotinic receptor. Nature, 538, 2016
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8SID
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![BU of 8sid by Molmil](/molmil-images/mine/8sid) | |
8SGO
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![BU of 8sgo by Molmil](/molmil-images/mine/8sgo) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2023-04-12 | 公開日 | 2023-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structural insights into opposing actions of neurosteroids on GABA A receptors. Nat Commun, 14, 2023
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8SI9
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6UWZ
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![BU of 6uwz by Molmil](/molmil-images/mine/6uwz) | Cryo-EM structure of Torpedo acetylcholine receptor in complex with alpha-bungarotoxin | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | 著者 | Rahman, M.M, Teng, J, Worrell, B.T, Noveillo, C.M, Lee, M, Karlin, A, Stowell, M, Hibbs, R.E. | 登録日 | 2019-11-06 | 公開日 | 2020-04-15 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | 主引用文献 | Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins. Neuron, 106, 2020
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6X3Z
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![BU of 6x3z by Molmil](/molmil-images/mine/6x3z) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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6X3V
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![BU of 6x3v by Molmil](/molmil-images/mine/6x3v) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Etomidate, ... | 著者 | Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E. | 登録日 | 2020-05-21 | 公開日 | 2020-09-09 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585, 2020
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3C84
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![BU of 3c84 by Molmil](/molmil-images/mine/3c84) | Crystal structure of a complex of AChBP from aplysia californica and the neonicotinoid thiacloprid | 分子名称: | ISOPROPYL ALCOHOL, MAGNESIUM ION, Soluble acetylcholine receptor, ... | 著者 | Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W. | 登録日 | 2008-02-08 | 公開日 | 2008-05-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3C79
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![BU of 3c79 by Molmil](/molmil-images/mine/3c79) | Crystal structure of Aplysia californica AChBP in complex with the neonicotinoid imidacloprid | 分子名称: | (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, ISOPROPYL ALCOHOL, Soluble acetylcholine receptor | 著者 | Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W. | 登録日 | 2008-02-06 | 公開日 | 2008-05-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore. Proc.Natl.Acad.Sci.Usa, 105, 2008
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8EIZ
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![BU of 8eiz by Molmil](/molmil-images/mine/8eiz) | Cryo-EM structure of squid sensory receptor CRB1 | 分子名称: | N-benzyl-2-(2,6-dimethylanilino)-N,N-diethyl-2-oxoethan-1-aminium, Squid sensory receptor CRB1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, van Giesen, L, Kilian, P.B, Bai, X, Bellono, N.W, Hibbs, R.E. | 登録日 | 2022-09-15 | 公開日 | 2023-04-12 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Sensory specializations drive octopus and squid behaviour. Nature, 616, 2023
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8EIS
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![BU of 8eis by Molmil](/molmil-images/mine/8eis) | Cryo-EM structure of octopus sensory receptor CRT1 | 分子名称: | 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Octopus sensory receptor | 著者 | Kang, G, Kim, J.J, Allard, C.A.H, Valencia-Montoya, W.A, Bellono, N.W, Hibbs, R.E. | 登録日 | 2022-09-15 | 公開日 | 2023-04-12 | 最終更新日 | 2023-04-26 | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | 主引用文献 | Sensory specializations drive octopus and squid behaviour. Nature, 616, 2023
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8F6Y
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![BU of 8f6y by Molmil](/molmil-images/mine/8f6y) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-17 | 公開日 | 2023-06-07 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8ESK
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![BU of 8esk by Molmil](/molmil-images/mine/8esk) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, resting-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-10-14 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F6Z
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![BU of 8f6z by Molmil](/molmil-images/mine/8f6z) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-17 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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8F2S
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![BU of 8f2s by Molmil](/molmil-images/mine/8f2s) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E. | 登録日 | 2022-11-08 | 公開日 | 2023-06-07 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural interplay of anesthetics and paralytics on muscle nicotinic receptors. Nat Commun, 14, 2023
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