8DD3
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM
This is a non-PDB format compatible entry.
Summary for 8DD3
Entry DOI | 10.2210/pdb8dd3/pdb |
EMDB information | 27332 27333 |
Descriptor | Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate, ... (11 entities in total) |
Functional Keywords | human gabaa receptor, dmcm, membrane protein-immune system complex, membrane protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 9 |
Total formula weight | 365546.89 |
Authors | Zhu, S.,Hibbs, R.E. (deposition date: 2022-06-17, release date: 2022-08-17, Last modification date: 2023-11-15) |
Primary citation | Zhu, S.,Sridhar, A.,Teng, J.,Howard, R.J.,Lindahl, E.,Hibbs, R.E. Structural and dynamic mechanisms of GABA A receptor modulators with opposing activities. Nat Commun, 13:4582-4582, 2022 Cited by PubMed: 35933426DOI: 10.1038/s41467-022-32212-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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