8DD3

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM

This is a non-PDB format compatible entry.

Summary for 8DD3

• Entry DOI: 10.2210/pdb8dd3/pdb
• EMDB information: 27332 27333
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate, ... (11 entities in total)
• Functional Keywords: human gabaa receptor, dmcm, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 365546.89

Authors

Zhu, S.,Hibbs, R.E. (deposition date: 2022-06-17, release date: 2022-08-17, Last modification date: 2023-11-15)

• Primary citation: Zhu, S.,Sridhar, A.,Teng, J.,Howard, R.J.,Lindahl, E.,Hibbs, R.E.; Structural and dynamic mechanisms of GABA A receptor modulators with opposing activities.; Nat Commun, 13:4582-4582, 2022; PubMed: 35933426; DOI: 10.1038/s41467-022-32212-4

Experimental method

ELECTRON MICROSCOPY (2.9 Å)