Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DD3

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Gamma-aminobutyric acid receptor subunit beta-2	polymer	364	41810.1	2	UniProt (P47870) Pfam (PF02931) Pfam (PF02932) In PDB	Homo sapiens (human)	GABA(A) receptor subunit beta-2
2	B, D	Gamma-aminobutyric acid receptor subunit alpha-1	polymer	358	41061.2	2	UniProt (P14867) Pfam (PF02931) Pfam (PF02932) In PDB	Homo sapiens (human)	GABA(A) receptor subunit alpha-1
3	E	Gamma-aminobutyric acid receptor subunit gamma-2	polymer	417	47673.1	1	UniProt (P18507) Pfam (PF02931) Pfam (PF02932) In PDB	Homo sapiens (human)	GABA(A) receptor subunit gamma-2
4	I, L	Kappa Fab Light Chain	polymer	213	23505.9	2		Mus musculus (Mouse)
5	J, K	IgG2b Fab Heavy Chain	polymer	454	49811.0	2		Mus musculus (Mouse)
6	F, H, M	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
7	G	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1721.5	1	In PDB GlyTouCan (G40702WU)
8	N	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
9	A, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
10	A, C	GAMMA-AMINO-BUTANOIC ACID	non-polymer		103.1	2	Chemie (ABU)
11	A, C, D	methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate	non-polymer		314.3	3	Chemie (R63)

Sequence modifications

A, C: 1 - 307 (UniProt: P47870)
A, C: 315 - 340 (UniProt: P47870)

PDB	External Database	Details
Ser 308	-	linker
Gln 309	-	linker
Pro 310	-	linker
Ala 311	-	linker
Arg 312	-	linker
Ala 313	-	linker
Ala 314	-	linker
Asn 341	-	expression tag
Val 342	-	expression tag
Asp 343	-	expression tag
Gly 344	-	expression tag
Ser 345	-	expression tag
Gly 346	-	expression tag
Ala 347	-	expression tag
Thr 348	-	expression tag
Asn 349	-	expression tag
Phe 350	-	expression tag
Ser 351	-	expression tag
Leu 352	-	expression tag
Leu 353	-	expression tag
Lys 354	-	expression tag
Gln 355	-	expression tag
Ala 356	-	expression tag
Gly 357	-	expression tag
Asp 358	-	expression tag
Val 359	-	expression tag
Glu 360	-	expression tag
Glu 361	-	expression tag
Asn 362	-	expression tag
Pro 363	-	expression tag
Gly 364	-	expression tag

B, D: 1 - 312 (UniProt: P14867)

PDB	External Database	Details
Ser 313	-	expression tag
Gln 314	-	expression tag
Pro 315	-	expression tag
Ala 316	-	expression tag
Arg 317	-	expression tag
Ala 318	-	expression tag
Ala 319	-	expression tag
Lys 320	-	expression tag
Ile 321	-	expression tag
Asp 322	-	expression tag
Arg 323	-	expression tag
Leu 324	-	expression tag
Ser 325	-	expression tag
Arg 326	-	expression tag
Ile 327	-	expression tag
Ala 328	-	expression tag
Phe 329	-	expression tag
Pro 330	-	expression tag
Leu 331	-	expression tag
Leu 332	-	expression tag
Phe 333	-	expression tag
Gly 334	-	expression tag
Ile 335	-	expression tag
Phe 336	-	expression tag
Asn 337	-	expression tag
Leu 338	-	expression tag
Val 339	-	expression tag
Tyr 340	-	expression tag
Trp 341	-	expression tag
Ala 342	-	expression tag
Thr 343	-	expression tag
Tyr 344	-	expression tag
Leu 345	-	expression tag
Asn 346	-	expression tag
Arg 347	-	expression tag
Glu 348	-	expression tag
Pro 349	-	expression tag
Gln 350	-	expression tag
Leu 351	-	expression tag
Lys 352	-	expression tag
Ala 353	-	expression tag
Pro 354	-	expression tag
Thr 355	-	expression tag
Pro 356	-	expression tag
His 357	-	expression tag
Gln 358	-	expression tag

E: 1 - 322 (UniProt: P18507)

PDB	External Database	Details
Trp -36	-	expression tag
Ser -35	-	expression tag
His -34	-	expression tag
Pro -33	-	expression tag
Gln -32	-	expression tag
Phe -31	-	expression tag
Glu -30	-	expression tag
Lys -29	-	expression tag
Gly -28	-	expression tag
Gly -27	-	expression tag
Gly -26	-	expression tag
Ser -25	-	expression tag
Gly -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Ser -21	-	expression tag
Gly -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
Ala -16	-	expression tag
Trp -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
Pro -12	-	expression tag
Gln -11	-	expression tag
Phe -10	-	expression tag
Glu -9	-	expression tag
Lys -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag
Ser 323	-	expression tag
Gln 324	-	expression tag
Pro 325	-	expression tag
Ala 326	-	expression tag
Arg 327	-	expression tag
Ala 328	-	expression tag
Ala 329	-	expression tag
Lys 330	-	expression tag
Met 331	-	expression tag
Asp 332	-	expression tag
Ser 333	-	expression tag
Tyr 334	-	expression tag
Ala 335	-	expression tag
Arg 336	-	expression tag
Ile 337	-	expression tag
Phe 338	-	expression tag
Phe 339	-	expression tag
Pro 340	-	expression tag
Thr 341	-	expression tag
Ala 342	-	expression tag
Phe 343	-	expression tag
Cys 344	-	expression tag
Leu 345	-	expression tag
Phe 346	-	expression tag
Asn 347	-	expression tag
Leu 348	-	expression tag
Val 349	-	expression tag
Tyr 350	-	expression tag
Trp 351	-	expression tag
Val 352	-	expression tag
Ser 353	-	expression tag
Tyr 354	-	expression tag
Leu 355	-	expression tag
Tyr 356	-	expression tag
Leu 357	-	expression tag
Ser 358	-	expression tag
Arg 359	-	expression tag
Gly 360	-	expression tag
Ser 361	-	expression tag
Gly 362	-	expression tag
Ala 363	-	expression tag
Thr 364	-	expression tag
Asn 365	-	expression tag
Phe 366	-	expression tag
Ser 367	-	expression tag
Leu 368	-	expression tag
Leu 369	-	expression tag
Lys 370	-	expression tag
Gln 371	-	expression tag
Ala 372	-	expression tag
Gly 373	-	expression tag
Asp 374	-	expression tag
Val 375	-	expression tag
Glu 376	-	expression tag
Glu 377	-	expression tag
Asn 378	-	expression tag
Pro 379	-	expression tag
Gly 380	-	expression tag

Sequence viewer

Contents of the asymmetric unit

Polymers	Number of chains	9
Polymers	Total formula weight	360049.7
Branched	Number of molecules	5
Branched	Total formula weight	3905.6
Non-Polymers*	Number of molecules	7
Non-Polymers*	Total formula weight	1591.7
All*	Total formula weight	365546.9

*Water molecules are not included.

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)