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6XR2
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BU of 6xr2 by Molmil
Computationally designed right-handed alpha/alpha homotrimeric toroid with 3 repeats per subunit
分子名称: dTor_3x57R
著者Hallinan, J.P, Doyle, L, Bradley, P, Stoddard, B.L.
登録日2020-07-10
公開日2021-07-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
6XR1
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BU of 6xr1 by Molmil
Computationally designed right-handed alpha/alpha single-chain toroid with 9 repeats
分子名称: dTor_9x57R
著者Hallinan, J.P, Doyle, L, Bradley, P, Stoddard, B.L.
登録日2020-07-10
公開日2021-07-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
5ESP
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BU of 5esp by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-PanMI with coordinated Calcium ions
分子名称: CALCIUM ION, DNA (27-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-11-16
公開日2016-03-30
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.995 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
5THG
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BU of 5thg by Molmil
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
分子名称: CALCIUM ION, DNA (29-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2016-09-29
公開日2017-05-03
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.106 Å)
主引用文献The structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering
to be published
4Z20
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BU of 4z20 by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTGT Central Four
分子名称: CALCIUM ION, DNA (26-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-03-27
公開日2016-03-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4Z1Z
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BU of 4z1z by Molmil
Crystal Structure of Meganuclease I-SmaMI Bound to Uncleaveable DNA with a TTCT Central Four
分子名称: CALCIUM ION, DNA (28-MER), GLYCEROL, ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-03-27
公開日2016-03-30
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YHX
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BU of 4yhx by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-GpeMI Bound to Uncleaved DNA
分子名称: CALCIUM ION, DNA (27-MER), Ribosomal protein 3/homing endonuclease-like fusion protein
著者Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
登録日2015-02-27
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YIT
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BU of 4yit by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-AabMI Bound to Uncleaved DNA
分子名称: CALCIUM ION, DNA (25-MER), DNA (25MER), ...
著者Hallinan, J.P, Stoddard, B.L.
登録日2015-03-02
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YIS
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BU of 4yis by Molmil
Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ...
著者Hallinan, J.P, Kaiser, B.K, Stoddard, B.L.
登録日2015-03-02
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity.
Structure, 24, 2016
4YY2
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BU of 4yy2 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P212121
分子名称: SODIUM ION, dTor_3x33L
著者Hallinan, J.P, Bradley, P, Stoddard, B.L.
登録日2015-03-23
公開日2015-12-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.854 Å)
主引用文献Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
4YY5
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BU of 4yy5 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P43212
分子名称: dTor_3x33L
著者Hallinan, J.P, Bradley, P, Stoddard, B.L.
登録日2015-03-23
公開日2015-12-16
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
7RDR
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BU of 7rdr by Molmil
Circular tandem repeat protein with novel repeat topology and enhanced subunit contact surfaces
分子名称: Circular tendon repeat protein
著者Shen, B.W, Stoddard, B.L.
登録日2021-07-10
公開日2021-09-01
最終更新日2021-11-17
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
5T2O
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BU of 5t2o by Molmil
Engineered variant of I-OnuI meganuclease targeting the Anopheles AGAP011377 gene; harbors 53 point mutations relative to wild-type I-OnuI
分子名称: CALCIUM ION, DNA (26-MER), I-OnuI_e-ag011377
著者Stoddard, B.L, Werther, R.
登録日2016-08-23
公開日2017-05-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
5T2H
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BU of 5t2h by Molmil
Engineered variant of I-OnuI meganuclease targeting the Human TCRa gene; harbors 43 point mutations relative to wild-type I-OnuI
分子名称: CALCIUM ION, DNA (26-MER), I-OnuI_e-hTCRa
著者Stoddard, B.L, Werther, R.
登録日2016-08-23
公開日2017-05-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.517 Å)
主引用文献Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
5T2N
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BU of 5t2n by Molmil
Engineered variant of I-OnuI meganuclease targeting the Anopheles AGAP007280 gene; harbors 38 point mutations relative to wild-type I-OnuI
分子名称: CALCIUM ION, DNA (26-MER), I-OnuI_e-ag007820
著者Stoddard, B.L, Werther, R.
登録日2016-08-23
公開日2017-05-03
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.079 Å)
主引用文献Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
6UVW
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BU of 6uvw by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability
分子名称: CALCIUM ION, DNA (27-MER), I-OnuI-e-Therm
著者Werther, R, Stoddard, B.L.
登録日2019-11-04
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.551 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWK
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BU of 6uwk by Molmil
Engineered variant of I-OnuI meganuclease with improved stability and fully altered specificity targeting human chromosome 11 trans integration site
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
著者Werther, R, Stoddard, B.L.
登録日2019-11-05
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.533 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWJ
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BU of 6uwj by Molmil
Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity
分子名称: CALCIUM ION, DNA (27-MER), I-OnuI-e-Therm-hChr11v2
著者Werther, R, Stoddard, B.L.
登録日2019-11-05
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWH
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BU of 6uwh by Molmil
Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (26-MER), ...
著者Werther, R, Stoddard, B.L.
登録日2019-11-05
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.299 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UW0
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BU of 6uw0 by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and fully altered specificity targeting cholera toxin A subunit
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
著者Werther, R, Stoddard, B.L.
登録日2019-11-04
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWG
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BU of 6uwg by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and E178D mutation at catalytic site
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, DNA (26-MER), ...
著者Werther, R, Stoddard, B.L.
登録日2019-11-05
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020

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件を2024-11-06に公開中

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