6MRD
| ADP-bound human mitochondrial Hsp60-Hsp10 half-football complex | 分子名称: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | 著者 | Gomez-Llorente, Y, Jebara, F, Patra, M, Malik, R, Nissemblat, S, Azem, A, Hirsch, J.A, Ubarretxena-Belandia, I. | 登録日 | 2018-10-12 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin. Nat Commun, 11, 2020
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6MRC
| ADP-bound human mitochondrial Hsp60-Hsp10 football complex | 分子名称: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | 著者 | Gomez-Llorente, Y, Jebara, F, Patra, M, Malik, R, Nissemblat, S, Azem, A, Hirsch, J.A, Ubarretxena-Belandia, I. | 登録日 | 2018-10-12 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin. Nat Commun, 11, 2020
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7LF1
| Trimeric human Arginase 1 in complex with mAb3 | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb3 heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7LEZ
| Trimeric human Arginase 1 in complex with mAb1 - 2 hArg:2 mAb1 complex | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb1 heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7LEX
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7LEY
| Trimeric human Arginase 1 in complex with mAb5 | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb5 heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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7LF0
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7LF2
| Trimeric human Arginase 1 in complex with mAb4 | 分子名称: | Arginase-1, MANGANESE (II) ION, mAb4 monoclonal antibody heavy chain, ... | 著者 | Gomez-Llorente, Y, Scapin, G, Palte, R.L. | 登録日 | 2021-01-15 | 公開日 | 2021-09-01 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action. Commun Biol, 4, 2021
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8SK5
| Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH | 著者 | Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y. | 登録日 | 2023-04-18 | 公開日 | 2023-08-16 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants. Sci Rep, 13, 2023
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6V8P
| Structure of DNA Polymerase Zeta (Apo) | 分子名称: | DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ... | 著者 | Malik, R, Gomez-Llorente, Y, Ubarretxena-Belandia, I, Aggarwal, A.K. | 登録日 | 2019-12-11 | 公開日 | 2020-08-19 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis. Nat.Struct.Mol.Biol., 27, 2020
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7MD5
| Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gomez-Llorente, Y, Zhou, H, Scapin, G. | 登録日 | 2021-04-03 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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7MD4
| Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists | 分子名称: | Insulin B chain, Insulin chain A, Isoform Short of Insulin receptor, ... | 著者 | Gomez-Llorente, Y, Zhou, H, Scapin, G. | 登録日 | 2021-04-03 | 公開日 | 2022-02-23 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists. Nat Commun, 13, 2022
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5IL7
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8F1D
| Voltage-gated potassium channel Kv3.1 apo | 分子名称: | CHOLESTEROL, POTASSIUM ION, Potassium voltage-gated channel subfamily C member 1, ... | 著者 | Chen, Y, Ishchenko, A. | 登録日 | 2022-11-04 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1C
| Voltage-gated potassium channel Kv3.1 with novel positive modulator (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one (compound 4) | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (9M)-9-{5-chloro-6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-4-methylpyridin-3-yl}-2-methyl-7,9-dihydro-8H-purin-8-one, POTASSIUM ION, ... | 著者 | Chen, Y, Ishchenko, A. | 登録日 | 2022-11-04 | 公開日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Identification and structural and biophysical characterization of a positive modulator of human Kv3.1 channels. Proc.Natl.Acad.Sci.USA, 120, 2023
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6V93
| Structure of DNA Polymerase Zeta/DNA/dNTP Ternary Complex | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA, ... | 著者 | Malik, R, Kopylov, M, Jain, R, Ubarrextena-Belandia, I, Aggarwal, A.K. | 登録日 | 2019-12-13 | 公開日 | 2020-08-19 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis. Nat.Struct.Mol.Biol., 27, 2020
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