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1Y1D
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BU of 1y1d by Molmil
Crystal structure of transthyretin in complex with iododiflunisal
分子名称: 2',4'-DIFLUORO-4-HYDROXY-5-IODO-1,1'-BIPHENYL-3-CARBOXYLIC ACID, Transthyretin
著者Gales, L, Macedo-Ribeiro, S, Arsequell, G, Valencia, G, Saraiva, M.J, Damas, A.M.
登録日2004-11-18
公開日2005-07-26
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Human transthyretin in complex with iododiflunisal: structural features associated with a potent amyloid inhibitor.
Biochem.J., 388, 2005
3B56
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BU of 3b56 by Molmil
Crystal structure of transthyretin in complex with 3,5-diiodosalicylic acid
分子名称: 2-HYDROXY-3,5-DIIODO-BENZOIC ACID, Transthyretin
著者Gales, L, Damas, A.M.
登録日2007-10-25
公開日2008-01-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Iodination of salicylic acid improves its binding to transthyretin
Biochim.Biophys.Acta, 1784, 2008
2H4E
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BU of 2h4e by Molmil
Crystal structure of Cys10 sulfonated transthyretin
分子名称: SULFATE ION, Transthyretin
著者Gales, L, Damas, A.M.
登録日2006-05-24
公開日2007-01-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for the protective role of sulfite against transthyretin amyloid formation.
Biochim.Biophys.Acta, 1774, 2007
3FCB
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BU of 3fcb by Molmil
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH
分子名称: N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINE, transthyretin
著者Gales, L, Damas, A.M.
登録日2008-11-21
公開日2009-02-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4, 2009
3FC8
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BU of 3fc8 by Molmil
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe
分子名称: METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE, transthyretin
著者Gales, L, Damas, A.M.
登録日2008-11-21
公開日2009-02-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4, 2009
4UB9
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BU of 4ub9 by Molmil
Structural and catalytic characterization of molinate hydrolase
分子名称: Molinate hydrolase, ZINC ION
著者Leite, J.P, Duarte, M, Paiva, A, Ferreira-da-Silva, F, Matias, P.M, Nunes, O, Gales, L.
登録日2014-08-12
公開日2015-06-24
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Structure-guided engineering of molinate hydrolase for the degradation of thiocarbamate pesticides.
Plos One, 10, 2015
3SSG
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BU of 3ssg by Molmil
Structure of transthyretin L55P in complex with Zn
分子名称: CACODYLATE ION, Transthyretin, ZINC ION
著者Castro-Rodrigues, A.F, Gales, L, Damas, A.M.
登録日2011-07-08
公開日2011-11-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils.
Acta Crystallogr.,Sect.D, 67, 2011
7ACU
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BU of 7acu by Molmil
Crystal structure of human transthyretin in complex with Benzbromarone
分子名称: Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone
著者Leite, J.P, Gales, L.
登録日2020-09-11
公開日2020-10-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.541 Å)
主引用文献Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer.
Int J Mol Sci, 21, 2020
7QH3
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BU of 7qh3 by Molmil
Crystal structure of the anti-sigma factor RsfG from Streptomyces tsukubaensis NRRL18488
分子名称: RsfG
著者Leite, J.P, Lourenco, F, Gales, L.
登録日2021-12-10
公開日2022-12-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG.
J.Struct.Biol., 215, 2023
7QH5
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BU of 7qh5 by Molmil
The crystal structure of the sigma factor SigG1 from Streptomyces tsukubaensis NRRL18488
分子名称: GLYCEROL, RNA polymerase sigma factor
著者Lourenco, F, Leite, J.P, Gales, L.
登録日2021-12-10
公開日2022-12-21
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of Streptomyces tsukubaensis sigma factor SigG1 and anti-sigma RsfG.
J.Struct.Biol., 215, 2023
2I5P
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BU of 2i5p by Molmil
Crystal structure of glyceraldehyde-3-phosphate dehydrogenase isoform 1 from K. marxianus
分子名称: BETA-MERCAPTOETHANOL, Glyceraldehyde-3-phosphate dehydrogenase 1, alpha-D-glucopyranose
著者Ferreira-da-Silva, F, Pereira, P.J.B, Gales, L, Moradas-Ferreira, P, Damas, A.M.
登録日2006-08-25
公開日2006-09-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Crystal and Solution Structures of Glyceraldehyde-3-phosphate Dehydrogenase Reveal Different Quaternary Structures.
J.Biol.Chem., 281, 2006
6EP1
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BU of 6ep1 by Molmil
Transthyretin in complex with 5-(4-nitrophenylazo)-3-iodosalicylic acid
分子名称: 5-(4-nitrophenylazo)-3-iodosalicylic acid, Transthyretin
著者Leite, J.P, Gales, L.
登録日2017-10-10
公開日2018-10-31
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease
Eur.J.Med.Chem., 2021
6GHX
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BU of 6ghx by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 31-35 in Complex with Cd-substituted Thermolysin
分子名称: CADMIUM ION, CALCIUM ION, DIMETHYL SULFOXIDE, ...
著者Leite, J.P, Gales, L.
登録日2018-05-09
公開日2019-02-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.156 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
6EOY
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BU of 6eoy by Molmil
Transthyretin in complex with 4-(1,3-Benzothiazol-2-yl)-2-methylaniline
分子名称: 4-(1,3-benzothiazol-2-yl)-2-methyl-aniline, Transthyretin
著者Leite, J.P, Gales, L.
登録日2017-10-10
公開日2021-10-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease.
Eur.J.Med.Chem., 226, 2021
5ONR
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BU of 5onr by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Thermolysin
分子名称: Amyloid-beta A4 protein, CALCIUM ION, DIMETHYL SULFOXIDE, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5ONQ
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BU of 5onq by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 29-40 in Complex with Cd-substituted Thermolysin
分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.17 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019
5O7B
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BU of 5o7b by Molmil
CRYSTAL STRUCTURE OF THE SLR0328 TYROSINE PHOSPHATASE WZB FROM SYNECHOCYSTIS SP. PCC 6803
分子名称: Putative low molecular weight protein-tyrosine-phosphatase slr0328
著者Leite, J.P, Gales, L.
登録日2017-06-08
公開日2018-06-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.281 Å)
主引用文献The role of the tyrosine kinase Wzc (Sll0923) and the phosphatase Wzb (Slr0328) in the production of extracellular polymeric substances (EPS) by Synechocystis PCC 6803.
Microbiologyopen, 2019
5ONP
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BU of 5onp by Molmil
Alzheimer's Amyloid-Beta Peptide Fragment 1-40 in Complex with Cd-substituted Thermolysin
分子名称: Amyloid-beta A4 protein, CADMIUM ION, CALCIUM ION, ...
著者Leite, J.P, Gales, L.
登録日2017-08-04
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Alzheimer's A beta1-40peptide degradation by thermolysin: evidence of inhibition by a C-terminal A beta product.
FEBS Lett., 593, 2019

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