3LBF
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![BU of 3lbf by Molmil](/molmil-images/mine/3lbf) | Crystal structure of Protein L-isoaspartyl methyltransferase from Escherichia coli | 分子名称: | GLYCEROL, PHOSPHATE ION, Protein-L-isoaspartate O-methyltransferase, ... | 著者 | Fang, P, Li, X, Wang, J, Niu, L, Teng, M. | 登録日 | 2010-01-08 | 公開日 | 2010-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of the protein L-isoaspartyl methyltransferase from Escherichia coli Cell Biochem.Biophys., 58, 2010
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4YCU
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![BU of 4ycu by Molmil](/molmil-images/mine/4ycu) | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ... | 著者 | Fang, P, Wang, J, Guo, M. | 登録日 | 2015-02-20 | 公開日 | 2015-06-10 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chem. Biol., 22, 2015
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4YCV
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4YCW
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![BU of 4ycw by Molmil](/molmil-images/mine/4ycw) | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | 著者 | Fang, P, Wang, J, Guo, M. | 登録日 | 2015-02-20 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor Chem.Biol., 22, 2015
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4P3O
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![BU of 4p3o by Molmil](/molmil-images/mine/4p3o) | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 2 | 分子名称: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | 著者 | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | 登録日 | 2014-03-09 | 公開日 | 2015-03-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.505 Å) | 主引用文献 | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun, 6, 2015
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4P3P
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![BU of 4p3p by Molmil](/molmil-images/mine/4p3p) | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 3 | 分子名称: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, GLYCEROL, Threonine--tRNA ligase, ... | 著者 | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | 登録日 | 2014-03-09 | 公開日 | 2015-03-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun, 6, 2015
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4P3N
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![BU of 4p3n by Molmil](/molmil-images/mine/4p3n) | Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1 | 分子名称: | (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ... | 著者 | Fang, P, Yu, X, Chen, K, Chen, X, Guo, M. | 登録日 | 2014-03-09 | 公開日 | 2015-03-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase. Nat Commun, 6, 2015
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3MNM
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![BU of 3mnm by Molmil](/molmil-images/mine/3mnm) | Crystal structure of GAE domain of GGA2p from Saccharomyces cerevisiae | 分子名称: | ADP-ribosylation factor-binding protein GGA2, GLYCEROL, SULFATE ION | 著者 | Fang, P, Wang, J, Li, X, Niu, L, Teng, M. | 登録日 | 2010-04-21 | 公開日 | 2010-09-08 | 最終更新日 | 2014-03-05 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structural basis for the specificity of the GAE domain of yGGA2 for its accessory proteins Ent3 and Ent5 Biochemistry, 49, 2010
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4DPG
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![BU of 4dpg by Molmil](/molmil-images/mine/4dpg) | Crystal Structure of Human LysRS: P38/AIMP2 Complex I | 分子名称: | ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | 著者 | Fang, P, Wang, J, Bennett, S.P, Guo, M. | 登録日 | 2012-02-13 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.844 Å) | 主引用文献 | Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription. Mol.Cell, 49, 2013
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4TTV
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![BU of 4ttv by Molmil](/molmil-images/mine/4ttv) | Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194 | 分子名称: | (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, Threonine--tRNA ligase, cytoplasmic, ... | 著者 | Fang, P, Guo, M. | 登録日 | 2014-06-23 | 公開日 | 2015-09-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci Rep, 5, 2015
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5YZX
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![BU of 5yzx by Molmil](/molmil-images/mine/5yzx) | Crystal structure of E.coli LysU T146D mutant | 分子名称: | BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CALCIUM ION, Lysine--tRNA ligase, ... | 著者 | Fang, P, Guo, M. | 登録日 | 2017-12-16 | 公開日 | 2018-12-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli To Be Published
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8K9X
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![BU of 8k9x by Molmil](/molmil-images/mine/8k9x) | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 5 (ADKI5) | 分子名称: | (2~{S})-2,6-bis(azanyl)-~{N}-[3-[2-[[4-[(2,5-dimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]phenyl]sulfonylpropyl]hexanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lysine--tRNA ligase | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | 登録日 | 2023-08-01 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7, 2024
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8K9V
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![BU of 8k9v by Molmil](/molmil-images/mine/8k9v) | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 3 (ADKI3) | 分子名称: | GLYCEROL, LYSINE, Lysine--tRNA ligase, ... | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | 登録日 | 2023-08-01 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7, 2024
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8K9S
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![BU of 8k9s by Molmil](/molmil-images/mine/8k9s) | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 1 (ADKI1) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LYSINE, Lysine--tRNA ligase, ... | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | 登録日 | 2023-08-01 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7, 2024
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8K9U
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![BU of 8k9u by Molmil](/molmil-images/mine/8k9u) | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 2 (ADKI2) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, LYSINE, Lysine--tRNA ligase, ... | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | 登録日 | 2023-08-01 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7, 2024
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8K9W
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![BU of 8k9w by Molmil](/molmil-images/mine/8k9w) | Crystal structure of plasmodium LysRS complexing with ASP3026 derived LysRS inhibitor 4 (ADKI4) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lysine--tRNA ligase, ~{N}2-(2-methoxyphenyl)-~{N}4-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine | 著者 | Zhou, J, Xia, M, Yang, G, Li, P, Fang, P. | 登録日 | 2023-08-01 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors. Commun Biol, 7, 2024
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6KA6
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![BU of 6ka6 by Molmil](/molmil-images/mine/6ka6) | Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 1 | 分子名称: | (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydroisochromen-1-one, GLYCEROL, LYSINE, ... | 著者 | Zhou, J, Fang, P. | 登録日 | 2019-06-21 | 公開日 | 2020-04-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.891 Å) | 主引用文献 | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
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6KCN
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![BU of 6kcn by Molmil](/molmil-images/mine/6kcn) | Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 4 | 分子名称: | 3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)isochromen-1-one, GLYCEROL, LYSINE, ... | 著者 | Zhou, J, Fang, P. | 登録日 | 2019-06-28 | 公開日 | 2020-04-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
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6KCT
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6KBF
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![BU of 6kbf by Molmil](/molmil-images/mine/6kbf) | Crystal structure of plasmodium lysyl-tRNA synthetase in complex with a cladosporin derivative 3 | 分子名称: | (3~{S})-3-[[(1~{S},3~{S})-3-methylcyclohexyl]methyl]-6,8-bis(oxidanyl)-3,4-dihydro-2~{H}-isoquinolin-1-one, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Zhou, J, Fang, P. | 登録日 | 2019-06-24 | 公開日 | 2020-04-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase. Acs Chem.Biol., 15, 2020
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8GS1
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![BU of 8gs1 by Molmil](/molmil-images/mine/8gs1) | Crystal structure of AziU2-U3 complex from Streptomyces sahachiroi NRRL2485 | 分子名称: | Azi28, Azi29, FORMIC ACID, ... | 著者 | Cheng, Y, Li, P, Liu, W, Fang, P. | 登録日 | 2022-09-04 | 公開日 | 2023-09-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Oxidase Heterotetramer Completes 1-Azabicyclo[3.1.0]hexane Formation with the Association of a Nonribosomal Peptide Synthetase. J.Am.Chem.Soc., 145, 2023
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2EXU
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![BU of 2exu by Molmil](/molmil-images/mine/2exu) | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ... | 著者 | Xu, F, Guo, M, Fang, P, Teng, M, Niu, L. | 登録日 | 2005-11-08 | 公開日 | 2006-11-08 | 最終更新日 | 2017-08-23 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain To be published
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7BT5
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![BU of 7bt5 by Molmil](/molmil-images/mine/7bt5) | Crystal structure of plasmodium LysRS complexing with an antitumor compound | 分子名称: | LYSINE, Lysine--tRNA ligase, N4-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-N2-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine | 著者 | Zhou, J, Wang, J, Fang, P. | 登録日 | 2020-03-31 | 公開日 | 2020-09-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.493 Å) | 主引用文献 | Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor. Nucleic Acids Res., 48, 2020
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8WIA
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![BU of 8wia by Molmil](/molmil-images/mine/8wia) | Crystal structure of E. coli ThrS catalytic domain mutant G463S | 分子名称: | Threonine--tRNA ligase, ZINC ION | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WIH
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![BU of 8wih by Molmil](/molmil-images/mine/8wih) | Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Threonine--tRNA ligase, ZINC ION | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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