4W99
 
 | | Apo-structure of the Y79F,W322E-double mutant of Etr1p | | 分子名称: | Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 1, mitochondrial, ... | | 著者 | Quade, N, Voegeli, B, Rosenthal, R, Erb, T.J. | | 登録日 | 2014-08-27 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The use of ene adducts to study and engineer enoyl-thioester reductases.
Nat.Chem.Biol., 11, 2015
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6GVS
 | | Engineered glycolyl-CoA reductase comprising 8 mutations with bound NADP+ | | 分子名称: | Aldehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION | | 著者 | Zarzycki, J, Trudeau, D, Scheffen, M, Erb, T.J, Tawfik, D.S. | | 登録日 | 2018-06-21 | | 公開日 | 2018-11-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.579 Å) | | 主引用文献 | Design and in vitro realization of carbon-conserving photorespiration.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6HR7
 | | HMG-CoA reductase from Methanothermococcus thermolithotrophicus apo form at 2.4 A resolution | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, GLYCEROL, ... | | 著者 | Wagner, T, Voegeli, B, Erb, T.J, Shima, S. | | 登録日 | 2018-09-26 | | 公開日 | 2019-02-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme.
Febs Lett., 593, 2019
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6HR8
 | | HMG-CoA reductase from Methanothermococcus thermolithotrophicus in complex with NADPH at 2.9 A resolution | | 分子名称: | DI(HYDROXYETHYL)ETHER, HMG-CoA reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Wagner, T, Voegeli, B, Erb, T.J, Shima, S. | | 登録日 | 2018-09-26 | | 公開日 | 2019-02-13 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of archaeal HMG-CoA reductase: insights into structural changes of the C-terminal helix of the class-I enzyme.
Febs Lett., 593, 2019
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5LB9
 | | Structure of the T175V Etr1p mutant in the monoclinic form P21 | | 分子名称: | Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 1, mitochondrial, ... | | 著者 | Wagner, T, Rosenthal, R.G, Voegeli, B, Shima, S, Erb, T.J. | | 登録日 | 2016-06-15 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A conserved threonine prevents self-intoxication of enoyl-thioester reductases.
Nat. Chem. Biol., 13, 2017
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5LBX
 | | Structure of the T175V Etr1p mutant in the trigonal form P312 in complex with NADP and crotonyl-CoA | | 分子名称: | CHLORIDE ION, CROTONYL COENZYME A, Enoyl-[acyl-carrier-protein] reductase [NADPH, ... | | 著者 | Wagner, T, Rosenthal, R.G, Voegeli, B, Shima, S, Erb, T.J. | | 登録日 | 2016-06-17 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A conserved threonine prevents self-intoxication of enoyl-thioester reductases.
Nat. Chem. Biol., 13, 2017
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8PN7
 | | Engineered glycolyl-CoA carboxylase (G20R variant) with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. | | 登録日 | 2023-06-30 | | 公開日 | 2023-11-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.03 Å) | | 主引用文献 | Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase.
Acs Synth Biol, 12, 2023
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8PN8
 | | Engineered glycolyl-CoA carboxylase (L100N variant) with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. | | 登録日 | 2023-06-30 | | 公開日 | 2023-11-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.31 Å) | | 主引用文献 | Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase.
Acs Synth Biol, 12, 2023
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8APR
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8APQ
 | | CaMct - Mesaconyl-CoA C1:C4 CoA Transferase of Chloroflexus aurantiacus | | 分子名称: | (2E)-2-METHYLBUT-2-ENEDIOIC ACID, 2-methylfumaryl-CoA isomerase, COENZYME A, ... | | 著者 | Pfister, P, Zarzycki, J, Erb, T.J. | | 登録日 | 2022-08-10 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Structural Basis for a Cork-Up Mechanism of the Intra-Molecular Mesaconyl-CoA Transferase.
Biochemistry, 62, 2023
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8AFV
 | | DaArgC3 - Engineered Formyl Phosphate Reductase with 3 substitutions (S178V, G182V, L233I) | | 分子名称: | N-acetyl-gamma-glutamyl-phosphate reductase, SODIUM ION | | 著者 | Pfister, P, Nattermann, M, Zarzycki, J, Erb, T.J. | | 登録日 | 2022-07-18 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | N-acetyl-gamma-glutamyl-phosphate reductase of Denitrovibrio acetiphilus
To Be Published
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8AFU
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8OIE
 | | Iron Nitrogenase Complex from Rhodobacter capsulatus | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | | 著者 | Schmidt, F.V, Schulz, L, Zarzycki, J, Prinz, S, Erb, T.J, Rebelein, J.G. | | 登録日 | 2023-03-22 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (2.35 Å) | | 主引用文献 | Structural insights into the iron nitrogenase complex.
Nat.Struct.Mol.Biol., 31, 2024
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8PBB
 | | CHAPSO treated partial catalytic component (comprising only AnfD & AnfK, lacking AnfG and FeFeco) of iron nitrogenase from Rhodobacter capsulatus | | 分子名称: | FE(8)-S(7) CLUSTER, Nitrogenase iron-iron protein, beta subunit, ... | | 著者 | Schmidt, F.V, Schulz, L, Zarzycki, J, Prinz, S, Erb, T.J, Rebelein, J.G. | | 登録日 | 2023-06-09 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Structural insights into the iron nitrogenase complex.
Nat.Struct.Mol.Biol., 31, 2024
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8CEI
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8CEJ
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8CEK
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8CIW
 | | Methylsuccinyl-CoA dehydrogenase from Pseudomonas migulae with bound FAD and (2S)-methylsuccinyl-CoA | | 分子名称: | (2S)-Methylsuccinyl-CoA, (2S)-methylsuccinyl-CoA dehydrogenase, CITRATE ANION, ... | | 著者 | Zarzycki, J, McLean, R, Erb, T.J. | | 登録日 | 2023-02-10 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO 2 fixation.
Sci Adv, 9, 2023
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6EQO
 | | Tri-functional propionyl-CoA synthase of Erythrobacter sp. NAP1 with bound NADP+ and phosphomethylphosphonic acid adenylate ester | | 分子名称: | Acetyl-coenzyme A synthetase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | | 著者 | Zarzycki, J, Bernhardsgruetter, I, Voegeli, B, Wagner, T, Engilberge, S, Girard, E, Shima, S, Erb, T.J. | | 登録日 | 2017-10-13 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite.
Nat. Chem. Biol., 14, 2018
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6EP8
 | | InhA Y158F mutant in complex with NADH from Mycobacterium tuberculosis | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL, ... | | 著者 | Wagner, T, Voegeli, B, Rosenthal, R.G, Stoffel, G, Shima, S, Kiefer, P, Cortina, N, Erb, T.J. | | 登録日 | 2017-10-11 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | InhA, the enoyl-thioester reductase fromMycobacterium tuberculosisforms a covalent adduct during catalysis.
J. Biol. Chem., 293, 2018
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6ES9
 | | Methylsuccinyl-CoA dehydrogenase of Paracoccus denitrificans with bound flavin adenine dinucleotide | | 分子名称: | Acyl-CoA dehydrogenase, COENZYME A, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Zarzycki, J, Schwander, T, Erb, T.J. | | 登録日 | 2017-10-19 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.37 Å) | | 主引用文献 | Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family.
J. Biol. Chem., 293, 2018
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6ET9
 | | Structure of the acetoacetyl-CoA-thiolase/HMG-CoA-synthase complex from Methanothermococcus thermolithotrophicus at 2.75 A | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Acetyl-CoA acetyltransferase thiolase, CHLORIDE ION, ... | | 著者 | Engilberge, S, Voegeli, B, Girard, E, Riobe, F, Maury, O, Erb, T.J, Shima, S, Wagner, T. | | 登録日 | 2017-10-25 | | 公開日 | 2018-03-14 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Archaeal acetoacetyl-CoA thiolase/HMG-CoA synthase complex channels the intermediate via a fused CoA-binding site.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6YBQ
 | | Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J. | | 登録日 | 2020-03-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (1.96 Å) | | 主引用文献 | A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
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6YBP
 | | Propionyl-CoA carboxylase of Methylorubrum extorquens with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J. | | 登録日 | 2020-03-17 | | 公開日 | 2020-10-28 | | 最終更新日 | 2021-05-12 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
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4WAS
 | | STRUCTURE OF THE ETR1P/NADP/CROTONYL-COA COMPLEX | | 分子名称: | CROTONYL COENZYME A, Enoyl-[acyl-carrier-protein] reductase [NADPH, B-specific] 1, ... | | 著者 | Quade, N, Voegeli, B, Rosenthal, R, Capitani, G, Erb, T.J. | | 登録日 | 2014-08-31 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The use of ene adducts to study and engineer enoyl-thioester reductases.
Nat.Chem.Biol., 11, 2015
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