6EP8

InhA Y158F mutant in complex with NADH from Mycobacterium tuberculosis

Summary for 6EP8

Entry DOI	10.2210/pdb6ep8/pdb
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], SODIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (6 entities in total)
Functional Keywords	mycolic acid biosynthetic process, oxidoreductase, therapeutic target, isoniazid, mutation, catalytic mechanism, enoyl thioester reductases, tuberculosis
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	1
Total formula weight	30247.18
Authors	Wagner, T.,Voegeli, B.,Rosenthal, R.G.,Stoffel, G.,Shima, S.,Kiefer, P.,Cortina, N.,Erb, T.J. (deposition date: 2017-10-11, release date: 2018-09-19, Last modification date: 2024-01-17)
Primary citation	Vogeli, B.,Rosenthal, R.G.,Stoffel, G.M.M.,Wagner, T.,Kiefer, P.,Cortina, N.S.,Shima, S.,Erb, T.J. InhA, the enoyl-thioester reductase fromMycobacterium tuberculosisforms a covalent adduct during catalysis. J. Biol. Chem., 293:17200-17207, 2018 Cited by PubMed: 30217823 DOI: 10.1074/jbc.RA118.005405 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation