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6EP8

InhA Y158F mutant in complex with NADH from Mycobacterium tuberculosis

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Enoyl-[acyl-carrier-protein] reductase [NADH]polymer27228821.11UniProt (P9WGR1)
Pfam (PF13561)
Mycobacterium tuberculosis H37RvEnoyl-ACP reductase,FAS-II enoyl-ACP reductase,NADH-dependent 2-trans-enoyl-ACP reductase
2B, D, E, F
(A)
SODIUM IONnon-polymer23.04Chemie (NA)
3C
(A)
NICOTINAMIDE-ADENINE-DINUCLEOTIDEnon-polymer663.41Chemie (NAD)
4G, H, I, J, K...
(A)
GLYCEROLnon-polymer92.16Chemie (GOL)
5M
(A)
(4S)-2-METHYL-2,4-PENTANEDIOLnon-polymer118.21Chemie (MPD)
6N
(A)
waterwater18.0264Chemie (HOH)
Sequence modifications
A: 1 - 269 (UniProt: P9WGR1)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ser -1-expression tag
His 0-expression tag
Phe 158Tyr 158engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight28821.1
Non-Polymers*Number of molecules12
Total formula weight1426.1
All*Total formula weight30247.2
*Water molecules are not included.

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PDB entries from 2025-07-23

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