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7Z43
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BU of 7z43 by Molmil
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Drncova, P.
登録日2022-03-03
公開日2022-05-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.123 Å)
主引用文献Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
7Z42
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BU of 7z42 by Molmil
Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B
分子名称: DNA-directed RNA polymerase II subunit RPB1, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Drncova, P.
登録日2022-03-03
公開日2022-05-18
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.418 Å)
主引用文献Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
6QCX
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BU of 6qcx by Molmil
Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer
分子名称: MAGNESIUM ION, PHOSPHATE ION, PYROPHOSPHATE 2-, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.08 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCV
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BU of 6qcv by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP
分子名称: CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.24 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCW
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BU of 6qcw by Molmil
Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Drncova, P.
登録日2018-12-31
公開日2019-06-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.88 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
7R0E
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BU of 7r0e by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-02-01
公開日2022-12-28
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.51 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7R1F
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BU of 7r1f by Molmil
Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-02-02
公開日2022-12-28
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.58 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7QTL
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BU of 7qtl by Molmil
Influenza A/H7N9 polymerase elongation complex
分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
著者Cusack, S, Kouba, T.
登録日2022-01-14
公開日2022-12-28
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.48 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
6FHH
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BU of 6fhh by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Lukarska, M, Cusack, S.
登録日2018-01-14
公開日2019-01-30
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published
6FHI
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BU of 6fhi by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.
分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Lukarska, M, Cusack, S.
登録日2018-01-14
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
To Be Published
7Z4O
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BU of 7z4o by Molmil
Influenza A/H7N9 polymerase core dimer with Pol II pSer5 CTD peptide mimic bound in site 2A
分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Cusack, S, Pflug, A.
登録日2022-03-04
公開日2022-05-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.412 Å)
主引用文献Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Plos Pathog., 18, 2022
7ZPM
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BU of 7zpm by Molmil
Influenza A/H7N9 polymerase apo-protein dimer complex
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
著者Cusack, S, Kouba, T.
登録日2022-04-27
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.81 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
7ZPL
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BU of 7zpl by Molmil
Symmetric dimer of influenza A/H7N9 polymerase bound to 5' vRNA hook
分子名称: 5' vRNA, MAGNESIUM ION, Polymerase acidic protein, ...
著者Cusack, S, Kouba, T.
登録日2022-04-27
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BDR
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BU of 8bdr by Molmil
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-19
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BE0
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BU of 8be0 by Molmil
Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-20
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.34 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BEK
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BU of 8bek by Molmil
Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-21
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
8BF5
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BU of 8bf5 by Molmil
Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue
分子名称: 3' vRNA, 5' vRNA, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2022-10-24
公開日2022-12-28
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.96 Å)
主引用文献Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.
Cell Rep, 42, 2023
6QCS
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BU of 6qcs by Molmil
Influenza B polymerase pre-initiation complex
分子名称: 3 end, 5 end, Capped RNA, ...
著者Cusack, S, Kouba, T.
登録日2018-12-30
公開日2019-06-05
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6QCT
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BU of 6qct by Molmil
Influenza B polymerase elongation complex
分子名称: 3 end, 5 end, MAGNESIUM ION, ...
著者Cusack, S, Kouba, T.
登録日2018-12-30
公開日2019-06-05
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural snapshots of actively transcribing influenza polymerase.
Nat.Struct.Mol.Biol., 26, 2019
6SZV
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BU of 6szv by Molmil
Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only)
分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-02
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6SZU
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BU of 6szu by Molmil
Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence
分子名称: 5-oxidanyl-4-oxidanylidene-1-[(1-pyrrolo[2,3-b]pyridin-1-ylcyclopentyl)methyl]pyridine-3-carboxylic acid, MAGNESIUM ION, PYROPHOSPHATE 2-, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-02
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.41 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T0V
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BU of 6t0v by Molmil
Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase)
分子名称: 3' vRNA, 5' vRNA, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.02 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T0W
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BU of 6t0w by Molmil
Human Influenza B polymerase recycling complex
分子名称: Polymerase PB2, Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, ...
著者Wandzik, J.M, Kouba, T, Karuppasamy, M, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T2C
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BU of 6t2c by Molmil
Bat Influenza A polymerase recycling complex
分子名称: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-08
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.52 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020
6T0U
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BU of 6t0u by Molmil
Bat Influenza A polymerase product dissociation complex using 44-mer vRNA template with intact oligo(U) sequence
分子名称: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit, ...
著者Wandzik, J.M, Kouba, T, Cusack, S.
登録日2019-10-03
公開日2020-04-15
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Cell, 181, 2020

 

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