7VKM
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![BU of 7vkm by Molmil](/molmil-images/mine/7vkm) | Crystal structure of TrkA (G595R) kinase domain | 分子名称: | Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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7VKO
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![BU of 7vko by Molmil](/molmil-images/mine/7vko) | Crystal structure of TrkA kinase with repotrectinib | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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7VKN
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![BU of 7vkn by Molmil](/molmil-images/mine/7vkn) | Crystal structure of TrkA (G595R) kinase with repotrectinib | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
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9BLG
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![BU of 9blg by Molmil](/molmil-images/mine/9blg) | Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892 | 分子名称: | (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Bester, S.M, Wu, W.-I, Mou, T.-C. | 登録日 | 2024-04-30 | 公開日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy. Cancer Discov, 13, 2023
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5KVT
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![BU of 5kvt by Molmil](/molmil-images/mine/5kvt) | THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB | 分子名称: | Entrectinib, GLYCEROL, High affinity nerve growth factor receptor | 著者 | Jin, L, Yan, S, Wei, G, Li, G, Harris, J, Vernier, J.-M. | 登録日 | 2016-07-15 | 公開日 | 2017-12-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Antitumor Activity and Safety of the Pan-TRK, ROS1, and ALK inhibitor Entrectinib (RXDX-101): Combined Results from Two Phase I Trials To Be Published
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7RRG
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![BU of 7rrg by Molmil](/molmil-images/mine/7rrg) | |
7L1D
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![BU of 7l1d by Molmil](/molmil-images/mine/7l1d) | |
7L1B
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![BU of 7l1b by Molmil](/molmil-images/mine/7l1b) | |
7L1C
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![BU of 7l1c by Molmil](/molmil-images/mine/7l1c) | |