7L1D
Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide
Summary for 7L1D
Entry DOI | 10.2210/pdb7l1d/pdb |
Descriptor | HLA class I histocompatibility antigen, A alpha chain, Beta-2-microglobulin, Mutant PIK3CA peptide, ... (7 entities in total) |
Functional Keywords | t cell receptor, peptide major histocompatibility complex, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 95000.04 |
Authors | Ma, J.,Baker, B.M. (deposition date: 2020-12-14, release date: 2022-03-23, Last modification date: 2023-10-18) |
Primary citation | Chandran, S.S.,Ma, J.,Klatt, M.G.,Dundar, F.,Bandlamudi, C.,Razavi, P.,Wen, H.Y.,Weigelt, B.,Zumbo, P.,Fu, S.N.,Banks, L.B.,Yi, F.,Vercher, E.,Etxeberria, I.,Bestman, W.D.,Da Cruz Paula, A.,Aricescu, I.S.,Drilon, A.,Betel, D.,Scheinberg, D.A.,Baker, B.M.,Klebanoff, C.A. Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA. Nat Med, 28:946-957, 2022 Cited by PubMed: 35484264DOI: 10.1038/s41591-022-01786-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.11 Å) |
Structure validation
Download full validation report