7L1D
Crystal structure of human 21LT2-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | HLA class I histocompatibility antigen, A alpha chain | polymer | 274 | 31628.8 | 1 | UniProt (P04439) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | Human leukocyte antigen A,HLA-A |
2 | B | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C | Mutant PIK3CA peptide | polymer | 9 | 972.1 | 1 | UniProt (P42336) In PDB | Homo sapiens | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
4 | D | T cell receptor, alpha chain | polymer | 206 | 22681.9 | 1 | Homo sapiens (Human) | ||
5 | E | T cell receptor, beta chain | polymer | 249 | 27686.7 | 1 | Homo sapiens (Human) | ||
6 | E | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
7 | E | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
C: 1 - 9 (UniProt: P42336)
PDB | External Database | Details |
---|---|---|
Met 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Leu 2 | His 1047 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 94848.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 151.1 | |
All* | Total formula weight | 95000.0 |