7RRG

Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide

Summary for 7RRG

• Entry DOI: 10.2210/pdb7rrg/pdb
• Descriptor: HLA class I histocompatibility antigen, A alpha chain, Beta-2-microglobulin, T cell receptor, alpha chain, ... (7 entities in total)
• Functional Keywords: t cell receptor, peptide major histocompatibility complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 96285.00

Authors

Ma, J.,Baker, B.M. (deposition date: 2021-08-09, release date: 2022-03-23, Last modification date: 2023-10-18)

• Primary citation: Chandran, S.S.,Ma, J.,Klatt, M.G.,Dundar, F.,Bandlamudi, C.,Razavi, P.,Wen, H.Y.,Weigelt, B.,Zumbo, P.,Fu, S.N.,Banks, L.B.,Yi, F.,Vercher, E.,Etxeberria, I.,Bestman, W.D.,Da Cruz Paula, A.,Aricescu, I.S.,Drilon, A.,Betel, D.,Scheinberg, D.A.,Baker, B.M.,Klebanoff, C.A.; Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.; Nat Med, 28:946-957, 2022; PubMed: 35484264; DOI: 10.1038/s41591-022-01786-3

Experimental method

X-RAY DIFFRACTION (2.12 Å)