7RRG
Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HLA class I histocompatibility antigen, A alpha chain | polymer | 274 | 31628.8 | 1 | UniProt (P04439) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | Human leukocyte antigen A,HLA-A |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (D) | T cell receptor, alpha chain | polymer | 207 | 22922.5 | 1 | Homo sapiens (Human) | ||
| 4 | D (E) | T cell receptor, beta chain | polymer | 245 | 27685.0 | 1 | Homo sapiens (Human) | ||
| 5 | E (C) | Mutant PIK3CA peptide | polymer | 9 | 972.1 | 1 | UniProt (P42336) | Homo sapiens | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
| 6 | F, G, H, I, J... (A, B, D, C) | GLYCEROL | non-polymer | 92.1 | 13 | Chemie (GOL) | |||
| 7 | S, T, U, V, W (A, B, D, E, C) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
C: 1 - 9 (UniProt: P42336)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Leu 2 | His 1047 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 95087.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1197.2 | |
| All* | Total formula weight | 96285.0 |
