7RRG

Crystal structure of human 0606T1-2 TCR bound to HLA-A*03:01 in complex with a mutant PIK3CA peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HLA class I histocompatibility antigen, A alpha chain	polymer	274	31628.8	1	UniProt (P04439) Pfam (PF00129) Pfam (PF07654) In PDB	Homo sapiens (Human)	Human leukocyte antigen A,HLA-A
2	B	Beta-2-microglobulin	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	D	T cell receptor, alpha chain	polymer	207	22922.5	1		Homo sapiens (Human)
4	E	T cell receptor, beta chain	polymer	245	27685.0	1		Homo sapiens (Human)
5	C	Mutant PIK3CA peptide	polymer	9	972.1	1	UniProt (P42336) In PDB	Homo sapiens	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA
6	A, B, D, C	GLYCEROL	non-polymer		92.1	13	Chemie (GOL)
7		water	water		18.0	414	Chemie (HOH)

Sequence modifications

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 9 (UniProt: P42336)

PDB	External Database	Details
Leu 2	His 1047	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	95087.8
Non-Polymers*	Number of molecules	13
	Total formula weight	1197.2
All*	Total formula weight	96285.0

*Water molecules are not included.