5KVT

THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB

Summary for 5KVT

• Entry DOI: 10.2210/pdb5kvt/pdb
• Descriptor: High affinity nerve growth factor receptor, Entrectinib, GLYCEROL, ... (4 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase-transfer complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single- pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 34161.39

Authors

Jin, L.,Yan, S.,Wei, G.,Li, G.,Harris, J.,Vernier, J.-M. (deposition date: 2016-07-15, release date: 2017-12-27, Last modification date: 2023-10-04)

• Primary citation: Drilon, A.; Antitumor Activity and Safety of the Pan-TRK, ROS1, and ALK inhibitor Entrectinib (RXDX-101): Combined Results from Two Phase I Trials; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)