5KVT

THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	High affinity nerve growth factor receptor	polymer	293	33508.7	1	UniProt (P04629) Pfam (PF07714) In PDB	Homo sapiens (Human)	Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA
2	A	Entrectinib	non-polymer		560.6	1	Chemie (YMX)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	11	Chemie (HOH)

Sequence modifications

A: 501 - 787 (UniProt: P04629)

PDB	External Database	Details
His 788	-	expression tag
His 789	-	expression tag
His 790	-	expression tag
His 791	-	expression tag
His 792	-	expression tag
His 793	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33508.7
Non-Polymers*	Number of molecules	2
	Total formula weight	652.7
All*	Total formula weight	34161.4

*Water molecules are not included.