5KVT
THE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | High affinity nerve growth factor receptor | polymer | 293 | 33508.7 | 1 | UniProt (P04629) Pfam (PF07714) | Homo sapiens (Human) | Neurotrophic tyrosine kinase receptor type 1,TRK1-transforming tyrosine kinase protein,Tropomyosin-related kinase A,Tyrosine kinase receptor,Tyrosine kinase receptor A,Trk-A,gp140trk,p140-TrkA |
| 2 | B (A) | Entrectinib | non-polymer | 560.6 | 1 | Chemie (YMX) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 501 - 787 (UniProt: P04629)
| PDB | External Database | Details |
|---|---|---|
| His 788 | - | expression tag |
| His 789 | - | expression tag |
| His 790 | - | expression tag |
| His 791 | - | expression tag |
| His 792 | - | expression tag |
| His 793 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33508.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 652.7 | |
| All* | Total formula weight | 34161.4 |
