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6RY9
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BU of 6ry9 by Molmil
Winter flounder 1a-1 in SDS micelles
分子名称: Pleurocidin-like prepropolypeptide
著者Clarke, M, Mason, A.J.
登録日2019-06-10
公開日2020-07-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Winter flounder 1a-1 in SDS micelles
To Be Published
6S2D
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BU of 6s2d by Molmil
Winter flounder 1 in SDS micelles
分子名称: Pleurocidin-like prepropolypeptide
著者Clarke, M, Mason, A.J.
登録日2019-06-20
公開日2020-07-15
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Winter flounder 1 in SDS micelles
To Be Published
8C65
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BU of 8c65 by Molmil
Crystal structure of cutinase AdCut from Acidovorax delafieldii (PBS depolymerase)
分子名称: PBS(A) depolymerase
著者Zahn, M, Clark, M.
登録日2023-01-11
公開日2024-01-24
実験手法X-RAY DIFFRACTION (1.491 Å)
主引用文献Predictions of the substrate specificities of the plastic-degrading enzymes IsPETase and AdCut
To Be Published
6RYQ
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BU of 6ryq by Molmil
Winter flounder 1a in SDS micelles
分子名称: Pleurocidin-like prepropolypeptide
著者Mason, A.J, Clarke, M.
登録日2019-06-11
公開日2020-07-15
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Winter flounder 1a in SDS micelles
To Be Published
6RZC
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BU of 6rzc by Molmil
Winter flounder 4 in SDS micelles
分子名称: Pleurocidin-like peptide WF4
著者Mason, A.J, Clarke, M.
登録日2019-06-13
公開日2020-07-15
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Winter flounder 4 in SDS micelles
To Be Published
1DYL
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BU of 1dyl by Molmil
9 ANGSTROM RESOLUTION CRYO-EM RECONSTRUCTION STRUCTURE OF SEMLIKI FOREST VIRUS (SFV) AND FITTING OF THE CAPSID PROTEIN STRUCTURE IN THE EM DENSITY
分子名称: NUCLEOCAPSID PROTEIN
著者Mancini, E.J, Clarke, M, Gowen, B.E, Rutten, T, Fuller, S.D.
登録日2000-02-02
公開日2000-08-18
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (9 Å)
主引用文献Cryo-Electron Microscopy Reveals the Functional Organization of an Enveloped Virus, Semliki Forest Virus.
Mol.Cell, 5, 2000
7ZF1
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BU of 7zf1 by Molmil
Structure of ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA
分子名称: DNA (61-MER), Fanconi anemia group D2 protein, Fanconi anemia group I protein, ...
著者Lemonidis, K, Rennie, M.L, Arkinson, C, Streetley, J, Clarke, M, Chaugule, V.K, Walden, H.
登録日2022-03-31
公開日2022-11-16
最終更新日2023-02-08
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.
Embo J., 42, 2023
7ABK
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BU of 7abk by Molmil
Helical structure of PspA
分子名称: Chloroplast membrane-associated 30 kD protein
著者Junglas, B, Huber, S.T, Mann, D, Heidler, T, Clarke, M, Schneider, D, Sachse, C.
登録日2020-09-07
公開日2021-08-04
最終更新日2021-08-11
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献PspA adopts an ESCRT-III-like fold and remodels bacterial membranes.
Cell, 184, 2021
8CXC
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BU of 8cxc by Molmil
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
分子名称: 3F2 Antibody heavy chain, 3F2 Antibody light chain, Mesothelin, ...
著者Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E.
登録日2022-05-20
公開日2023-06-07
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (4.31 Å)
主引用文献Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics
Front. Drug Discov., 3, 2023
8CYH
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BU of 8cyh by Molmil
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, A12 antibody heavy chain, A12 antibody light chain, ...
著者Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E.
登録日2022-05-23
公開日2023-06-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.38 Å)
主引用文献Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics
Front. Drug Discov., 3, 2023
8CZ8
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BU of 8cz8 by Molmil
Novel Anti-Mesothelin Antibodies Enable Crystallography of the Intact Mesothelin Ectodo- main and Engineering of Potent, T cell-engaging Bispecific Therapeutics
分子名称: Mesothelin, cleaved form, SULFATE ION, ...
著者Bandaranayake, A.D, Rupert, P.B, Lin, I, Pilat, K, Ruff, R.O, Friend, D.J, Chan, M.K, Clarke, M, Carter, J, Meshinchi, S, Mehlin, C, Olson, J.M, Strong, R.K, Correnti, C.E.
登録日2022-05-24
公開日2023-06-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Novel mesothelin antibodies enable crystallography of the intact mesothelin ectodomain and engineering of potent, T cell-engaging bispecific therapeutics
Front. Drug Discov., 3, 2023
6EHL
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BU of 6ehl by Molmil
Model of the Ebola virus nucleoprotein in recombinant nucleocapsid-like assemblies
分子名称: Nucleoprotein
著者Wan, W, Kolesnikova, L, Clarke, M, Koehler, A, Noda, T, Becker, S, Briggs, J.A.G.
登録日2017-09-13
公開日2017-11-08
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
6RZ1
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BU of 6rz1 by Molmil
Winter flounder 3 in SDS micelles
分子名称: Pleurocidin-like peptide WF3
著者Mason, A.J, Clarke, M.
登録日2019-06-12
公開日2020-07-15
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Structure of winter flounder AMP 3
To Be Published
6EHM
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BU of 6ehm by Molmil
Model of the Ebola virus nucleocapsid subunit from recombinant virus-like particles
分子名称: Membrane-associated protein VP24, Nucleoprotein
著者Wan, W, Kolesnikova, L, Clarke, M, Koehler, A, Noda, T, Becker, S, Briggs, J.A.G.
登録日2017-09-13
公開日2017-11-08
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (7.3 Å)
主引用文献Structure and assembly of the Ebola virus nucleocapsid.
Nature, 551, 2017
2N2H
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BU of 2n2h by Molmil
Solution structure of Sds3 in complex with Sin3A
分子名称: Paired amphipathic helix protein Sin3a, Sin3 histone deacetylase corepressor complex component SDS3
著者Clark, M, Radhakrishnan, I.
登録日2015-05-08
公開日2015-07-15
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
6OBA
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BU of 6oba by Molmil
The beta2 adrenergic receptor bound to a negative allosteric modulator
分子名称: (2S)-1-[(1-methylethyl)amino]-3-(2-prop-2-en-1-ylphenoxy)propan-2-ol, 6-bromo-N~2~-phenylquinazoline-2,4-diamine, Beta-2 adrenergic receptor,Lysozyme,Beta-2 adrenergic receptor, ...
著者Liu, X, Stobel, A, Kaindl, J, Dengler, D, ClarK, M, Mahoney, J, Korczynska, M, Matt, R.A, Hubner, H, Xu, X, Stanek, M, Hirata, K, Shoichet, B, Sunahara, R, Gmeiner, R, Kobilka, B.K.
登録日2019-03-20
公開日2020-03-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献An allosteric modulator binds to a conformational hub in the beta2adrenergic receptor.
Nat.Chem.Biol., 16, 2020
5CJO
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BU of 5cjo by Molmil
Crystal Structure Analysis of Elbow-Engineered-Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FAB Heavy chain with engineered elbow, FAB light chain, ...
著者liang, w.g, bailey, L, tang, w.j.
登録日2015-07-14
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.287 Å)
主引用文献Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
J. Mol. Biol., 2017
7XK9
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BU of 7xk9 by Molmil
Structure of human beta2 adrenergic receptor bound to constrained isoproterenol
分子名称: (5R,6R)-6-(propan-2-ylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ...
著者Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P.
登録日2022-04-19
公開日2023-04-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.
Nat Commun, 14, 2023
7XKA
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BU of 7xka by Molmil
Structure of human beta2 adrenergic receptor bound to constrained epinephrine
分子名称: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Camelid Antibody Fragment, Endolysin,Beta-2 adrenergic receptor, ...
著者Xu, X, Shonberg, J, Kaindl, J, Clark, M, Stobel, A, Maul, L, Mayer, D, Hubner, H, Venkatakrishnan, A, Dror, R, Kobilka, B.K, Sunahara, R, Liu, X, Gmeiner, P.
登録日2022-04-19
公開日2023-04-26
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Constrained catecholamines gain beta 2 AR selectivity through allosteric effects on pocket dynamics.
Nat Commun, 14, 2023
7AW0
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BU of 7aw0 by Molmil
MerTK kinase domain in complex with purine inhibitor
分子名称: 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine, Tyrosine-protein kinase Mer
著者Schimpl, M, Nissink, J.W.M, Blackett, C, Clarke, M, Disch, J, Goldberg, K, Guilinger, J, Hennessy, E.J, Jetson, R, Ginkunja, D, Hardaker, E, Keefe, A, McCoull, W, McMurray, L, Collingwood, O, Overman, R, Pflug, A, Preston, M, Rawlins, P, Rivers, E, Smith, P, Underwood, E, Truman, C, Warwicker, J, Winter, J, Woodcock, S, Zhang, Y.
登録日2020-11-06
公開日2021-03-03
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.893 Å)
主引用文献Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64, 2021
7BVQ
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BU of 7bvq by Molmil
Structure of human beta1 adrenergic receptor bound to carazolol
分子名称: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, CHOLESTEROL, ...
著者Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X.
登録日2020-04-11
公開日2020-12-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.
Cell Res., 31, 2021
7BU6
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BU of 7bu6 by Molmil
Structure of human beta1 adrenergic receptor bound to norepinephrine and nanobody 6B9
分子名称: (2S)-2,3-dihydroxypropyl octanoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ...
著者Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X.
登録日2020-04-04
公開日2020-12-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.
Cell Res., 31, 2021
7BU7
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BU of 7bu7 by Molmil
Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, ...
著者Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X.
登録日2020-04-04
公開日2020-12-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.
Cell Res., 31, 2021
7BTS
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BU of 7bts by Molmil
Structure of human beta1 adrenergic receptor bound to epinephrine and nanobody 6B9
分子名称: (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ...
著者Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X.
登録日2020-04-02
公開日2020-12-02
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.13 Å)
主引用文献Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR.
Cell Res., 31, 2021
4ZQA
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BU of 4zqa by Molmil
Crystal Structure of the Sds3 Dimerization Domain
分子名称: Sin3 histone deacetylase corepressor complex component SDS3
著者Chan, C.W, Mondragon, A, Clark, M, Radhakrishnan, I.
登録日2015-05-08
公開日2015-07-15
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.
Proc.Natl.Acad.Sci.USA, 112, 2015

 

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