9FB2

Gcase in complex with small molecule inhibitor 1

This is a non-PDB format compatible entry.

Summary for 9FB2

• Entry DOI: 10.2210/pdb9fb2/pdb
• Descriptor: Lysosomal acid glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: glycosidase, cholesterol metabolism, steroid metabolism, glycosyl transferase, lipid binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 63295.78

Authors

Tisi, D.,Cleasby, A. (deposition date: 2024-05-11, release date: 2024-07-03)

• Primary citation: Palmer, N.,Agnew, C.,Benn, C.,Buffham, W.J.,Castro, J.N.,Chessari, G.,Clark, M.,Cons, B.D.,Coyle, J.E.,Dawson, L.A.,Hamlett, C.C.F.,Hodson, C.,Holding, F.,Johnson, C.N.,Liebeschuetz, J.W.,Mahajan, P.,McCarthy, J.M.,Murray, C.W.,O'Reilly, M.,Peakman, T.,Price, A.,Rapti, M.,Reeks, J.,Schopf, P.,St-Denis, J.D.,Valenzano, C.,Wallis, N.G.,Walser, R.,Weir, H.,Wilsher, N.E.,Woodhead, A.,Bento, C.F.,Tisi, D.; Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of beta-Glucocerebrosidase.; J.Med.Chem., 2024; PubMed: 38932616; DOI: 10.1021/acs.jmedchem.4c00702

Experimental method

X-RAY DIFFRACTION (1.14 Å)