9FB2

Gcase in complex with small molecule inhibitor 1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004348	molecular_function	glucosylceramidase activity
A	0006665	biological_process	sphingolipid metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:15817452

Chain	Residue	Details
A	GLU274

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:15817452

Chain	Residue	Details
A	GLU379

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12792654, ECO:0000269|PubMed:17139081

Chain	Residue	Details
A	ASN58

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:17139081, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN98

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:17139081

Chain	Residue	Details
A	ASN185

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN309

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN501

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 764

Chain	Residue	Details
A	GLU274	activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
A	GLU379	covalently attached, nucleofuge, nucleophile
A	CYS381	electrostatic stabiliser
A	ASN409

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