1KY7
 
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1KYF
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1KYU
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1KYD
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1KY6
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1R0D
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5ELI
 | | Triggering receptor expressed on myeloid cells 2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Triggering receptor expressed on myeloid cells 2 | | 著者 | Brett, T.J, Kober, D.L. | | 登録日 | 2015-11-04 | | 公開日 | 2016-12-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.0977 Å) | | 主引用文献 | Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
Elife, 5, 2016
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6BA8
 | | YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway | | 分子名称: | Iron aquisition yersiniabactin synthesis enzyme, YbtT | | 著者 | Brett, T.J, Kober, D.L, Ohlemacher, S.I, Henderson, J.P. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.
J. Biol. Chem., 293, 2018
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6BA9
 | | YbtT - Type II thioesterase from Yersiniabactin NRPS/PKS biosynthetic pathway- S89A mutant | | 分子名称: | Iron aquisition yersiniabactin synthesis enzyme, YbtT | | 著者 | Brett, T.J, Kober, D.L, Ohlemacher, S.I, Henderson, J.P. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | YbtT is a low-specificity type II thioesterase that maintains production of the metallophore yersiniabactin in pathogenic enterobacteria.
J. Biol. Chem., 293, 2018
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5EKN
 | | Crystal structure of MAPK13 complex with inhibitor | | 分子名称: | 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-ylsulfanyl)phenyl]urea, Mitogen-activated protein kinase 13 | | 著者 | Brett, T.J, Miller, C.A, Yurtsever, Z. | | 登録日 | 2015-11-03 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | | 主引用文献 | First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Biochim.Biophys.Acta, 1860, 2016
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5EKO
 | | Crystal structure of MAPK13 complex with inhibitor | | 分子名称: | 3-(4-methyl-1H-imidazol-1-yl)-N-[4-(pyridin-4-yloxy)phenyl]benzamide, Mitogen-activated protein kinase 13 | | 著者 | Brett, T.J, Miller, C.A, Yurtsever, Z. | | 登録日 | 2015-11-03 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | First comprehensive structural and biophysical analysis of MAPK13 inhibitors targeting DFG-in and DFG-out binding modes.
Biochim.Biophys.Acta, 1860, 2016
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6PYO
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6PYX
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4YNO
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3NI0
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4MYG
 | | MAPK13, active form | | 分子名称: | Mitogen-activated protein kinase 13 | | 著者 | Yurtsever, Z, Brett, T.J, Scheaffer, S.M. | | 登録日 | 2013-09-27 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.594 Å) | | 主引用文献 | The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.
Acta Crystallogr.,Sect.D, 71, 2015
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4EYJ
 | | MAPK13 Complex with inhibitor | | 分子名称: | 1-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-3-[4-(pyridin-4-yloxy)phenyl]urea, Mitogen-activated protein kinase 13 | | 著者 | Miller, C.A, Brett, T.J. | | 登録日 | 2012-05-01 | | 公開日 | 2012-12-19 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | | 主引用文献 | IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
J.Clin.Invest., 122, 2012
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4EYM
 | | MAPK13 complex with inhibitor | | 分子名称: | 2-(morpholin-4-yl)-N-[4-(pyridin-4-yloxy)phenyl]pyridine-4-carboxamide, Mitogen-activated protein kinase 13 | | 著者 | Miller, C.A, Brett, T.J. | | 登録日 | 2012-05-01 | | 公開日 | 2012-12-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | | 主引用文献 | IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
J.Clin.Invest., 122, 2012
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4U2X
 | | Ebola virus VP24 in complex with Karyopherin alpha 5 C-terminus | | 分子名称: | CHLORIDE ION, Importin subunit alpha-6, Membrane-associated protein VP24 | | 著者 | Xu, W, Leung, D, Borek, D, Amarasinghe, G. | | 登録日 | 2014-07-18 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.153 Å) | | 主引用文献 | Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.
Cell Host Microbe, 16, 2014
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1ML0
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1MKF
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