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3TCQ
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BU of 3tcq by Molmil
Crystal Structure of matrix protein VP40 from Ebola virus Sudan
分子名称: Matrix protein VP40
著者Clifton, M.C, Edwards, T.E, Anderson, V, Atkins, K, Raymond, A, Saphire, E.O, Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-08-09
公開日2012-10-03
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.
J Infect Dis, 212 Suppl 2, 2015
4FN2
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BU of 4fn2 by Molmil
Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37
分子名称: Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase, ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-06-19
公開日2012-08-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
3UF8
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BU of 3uf8 by Molmil
Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-10-31
公開日2011-11-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
3UQA
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BU of 3uqa by Molmil
Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-11-19
公開日2011-12-07
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
5J5T
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BU of 5j5t by Molmil
GLK co-crystal structure with aminopyrrolopyrimidine inhibitor
分子名称: 5-[2-(piperidin-4-yl)-1,3-thiazol-5-yl]-3-[(pyridin-4-yl)methoxy]pyridin-2-amine, Mitogen-activated protein kinase kinase kinase kinase 3
著者Silvian, L.F, Marcotte, D.
登録日2016-04-03
公開日2016-10-26
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.
Protein Sci., 26, 2017
5E0I
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BU of 5e0i by Molmil
Crystal structure of the HBV capsid Y132A mutant (VCID 8772) in complex with NVR10-001E2 at 1.95A resolution
分子名称: Capsid protein, methyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)pyrimidine-5-carboxylate
著者Lukacs, C.M, Abendroth, J, Klumpp, K.
登録日2015-09-28
公開日2015-12-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.
Proc.Natl.Acad.Sci.USA, 112, 2015
3UQB
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BU of 3uqb by Molmil
Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3, Peptidyl-prolyl cis-trans isomerase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-11-19
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
3VAW
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BU of 3vaw by Molmil
Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Ubiquitin-like protein SMT3,Peptidyl-prolyl cis-trans isomerase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-12-29
公開日2012-01-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
4DZ3
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BU of 4dz3 by Molmil
Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation M61H from Burkholderia pseudomallei complexed with FK506
分子名称: 1,2-ETHANEDIOL, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ACETATE ION, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-02-29
公開日2012-03-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
4DZ2
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BU of 4dz2 by Molmil
Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation R92G from Burkholderia pseudomallei complexed with FK506
分子名称: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-02-29
公開日2012-03-28
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
5WHK
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BU of 5whk by Molmil
Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Beta-2-microglobulin, ...
著者Edwards, T.E, Clifton, M.C, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
5WHJ
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BU of 5whj by Molmil
Crystal structure of Fab fragment of anti-FcRn antibody DX-2507
分子名称: DX-2507 Fab heavy chain, DX-2507 Fab light chain
著者Edwards, T.E, Fairman, J.W, Nixon, A.E, Kenniston, J.A.
登録日2017-07-17
公開日2017-09-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody.
J. Biol. Chem., 292, 2017
4G50
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BU of 4g50 by Molmil
Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168
分子名称: 1,2-ETHANEDIOL, 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, FORMIC ACID, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-07-17
公開日2012-08-01
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
4GIV
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BU of 4giv by Molmil
Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183
分子名称: 3-(pyridin-3-yl)propyl (2S)-1-[(3-nitrophenyl)sulfonyl]piperidine-2-carboxylate, FORMIC ACID, Ubiquitin-like protein SMT3, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-08-09
公開日2012-09-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
4GGQ
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BU of 4ggq by Molmil
Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40
分子名称: 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2012-08-07
公開日2012-08-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.
Antimicrob.Agents Chemother., 58, 2014
3V7O
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BU of 3v7o by Molmil
Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)
分子名称: 1,2-ETHANEDIOL, Minor nucleoprotein VP30
著者Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2011-12-21
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure of the Reston ebolavirus VP30 C-terminal domain.
Acta Crystallogr F Struct Biol Commun, 70, 2014
4XUZ
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BU of 4xuz by Molmil
Structure of CTX-M-15 bound to RPX-7009 at 1.5 A
分子名称: 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ...
著者Clifton, M.C, Gardberg, A.
登録日2015-01-26
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J.Med.Chem., 58, 2015
4XUX
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BU of 4xux by Molmil
Structure of ampC bound to RPX-7009 at 1.75 A
分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Beta-lactamase, ...
著者Clifton, M.C, Abendroth, J.
登録日2015-01-26
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Discovery of a Cyclic Boronic Acid beta-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.
J.Med.Chem., 58, 2015
7MFC
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BU of 7mfc by Molmil
Crystal structure of CSF1R in complex with vimseltinib
分子名称: Macrophage colony-stimulating factor 1 receptor, Vimseltinib
著者Abendroth, J, Davies, D.R, Atkins, K.
登録日2021-04-08
公開日2021-11-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages.
Mol.Cancer Ther., 20, 2021
3S41
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BU of 3s41 by Molmil
Glucokinase in complex with activator and glucose
分子名称: Glucokinase, N,N-dimethyl-5-({2-methyl-6-[(5-methylpyrazin-2-yl)carbamoyl]-1-benzofuran-4-yl}oxy)pyrimidine-2-carboxamide, SODIUM ION, ...
著者Liu, S.
登録日2011-05-18
公開日2011-09-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus
MEDCHEMCOMM, 2, 2011
5JQ1
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BU of 5jq1 by Molmil
Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic
分子名称: Asialoglycoprotein receptor 1, CALCIUM ION, CHLORIDE ION, ...
著者Liu, S.
登録日2016-05-04
公開日2017-06-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J. Am. Chem. Soc., 139, 2017
5JPV
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BU of 5jpv by Molmil
Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic
分子名称: Asialoglycoprotein receptor 1, CALCIUM ION, CHLORIDE ION, ...
著者Liu, S.
登録日2016-05-04
公開日2017-06-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J. Am. Chem. Soc., 139, 2017
4L3Q
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BU of 4l3q by Molmil
Crystal structure of glucokinase-activator complex
分子名称: 6-{3-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenyl}pyridin-2(1H)-one, Glucokinase, alpha-D-glucopyranose
著者Gajiwala, K.S, Filipski, K.J.
登録日2013-06-06
公開日2013-07-24
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg.Med.Chem.Lett., 23, 2013

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