5JPV
Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic
Summary for 5JPV
Entry DOI | 10.2210/pdb5jpv/pdb |
Related PRD ID | PRD_900008 |
Descriptor | Asialoglycoprotein receptor 1, beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | asialoglycoprotein receptor, carbohydrates, liver targeting, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform H1a: Membrane; Single-pass type II membrane protein. Isoform H1b: Secreted : P07306 |
Total number of polymer chains | 2 |
Total formula weight | 34983.65 |
Authors | |
Primary citation | Sanhueza, C.A.,Baksh, M.M.,Thuma, B.,Roy, M.D.,Dutta, S.,Preville, C.,Chrunyk, B.A.,Beaumont, K.,Dullea, R.,Ammirati, M.,Liu, S.,Gebhard, D.,Finley, J.E.,Salatto, C.T.,King-Ahmad, A.,Stock, I.,Atkinson, K.,Reidich, B.,Lin, W.,Kumar, R.,Tu, M.,Menhaji-Klotz, E.,Price, D.A.,Liras, S.,Finn, M.G.,Mascitti, V. Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor. J. Am. Chem. Soc., 139:3528-3536, 2017 Cited by PubMed: 28230359DOI: 10.1021/jacs.6b12964 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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