5WHK

Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M

Summary for 5WHK

Entry DOI	10.2210/pdb5whk/pdb
Descriptor	DX-2507 Fab heavy chain, DX-2507 Fab light chain, IgG receptor FcRn large subunit p51, ... (7 entities in total)
Functional Keywords	neonatal receptor, fc, antibody recycling, immune system
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Single-pass type I membrane protein : P55899 Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains	4
Total formula weight	92737.03
Authors	Edwards, T.E.,Clifton, M.C.,Nixon, A.E.,Kenniston, J.A. (deposition date: 2017-07-17, release date: 2017-09-06, Last modification date: 2023-10-04)
Primary citation	Kenniston, J.A.,Taylor, B.M.,Conley, G.P.,Cosic, J.,Kopacz, K.J.,Lindberg, A.P.,Comeau, S.R.,Atkins, K.,Bullen, J.,TenHoor, C.,Adelman, B.A.,Sexton, D.J.,Edwards, T.E.,Nixon, A.E. Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. J. Biol. Chem., 292:17449-17460, 2017 Cited by PubMed: 28878017 DOI: 10.1074/jbc.M117.807396 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation