5WHK

Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	DX-2507 Fab heavy chain	polymer	219	22981.7	1	UniProt (S6BAN1) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	L	DX-2507 Fab light chain	polymer	216	22660.0	1	UniProt (Q6NS95) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	A	IgG receptor FcRn large subunit p51	polymer	297	32824.0	1	UniProt (P55899) Pfam (PF00129) Pfam (PF07654) In PDB	Homo sapiens (Human)	FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor
4	B	Beta-2-microglobulin	polymer	119	13732.5	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (Human)
5	H, A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	A	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID	non-polymer		207.3	2	Chemie (NHE)
7		water	water		18.0	254	Chemie (HOH)

Sequence modifications

H: 1 - 105 (PDB: 5WHK)
H: 106 - 219 (UniProt: S6BAN1)
L: 1 - 98 (PDB: 5WHK)
L: 99 - 216 (UniProt: Q6NS95)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	92198.3
Non-Polymers*	Number of molecules	4
	Total formula weight	538.7
All*	Total formula weight	92737.0

*Water molecules are not included.