5WHK
Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | DX-2507 Fab heavy chain | polymer | 219 | 22981.7 | 1 | UniProt (S6BAN1) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B (L) | DX-2507 Fab light chain | polymer | 216 | 22660.0 | 1 | UniProt (Q6NS95) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (A) | IgG receptor FcRn large subunit p51 | polymer | 297 | 32824.0 | 1 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
| 4 | D (B) | Beta-2-microglobulin | polymer | 119 | 13732.5 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 5 | E, H (H, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | F, G (A) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 2 | Chemie (NHE) | |||
| 7 | I, J, K, L (H, L, A, B) | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
H: 1 - 105 (PDB: 5WHK)
H: 106 - 219 (UniProt: S6BAN1)
L: 1 - 98 (PDB: 5WHK)
L: 99 - 216 (UniProt: Q6NS95)
H: 106 - 219 (UniProt: S6BAN1)
L: 1 - 98 (PDB: 5WHK)
L: 99 - 216 (UniProt: Q6NS95)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 92198.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 538.7 | |
| All* | Total formula weight | 92737.0 |
